ArticleGenome biology2005
Quantitative genomics of starvation stress resistance in Drosophila.
Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed, 114 citations in OpenAlex.
- Gene and transposable element expression in response to stress in temperate and tropical populations of Drosophila.Mobile DNA · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Reference genes to study the sex-biased expression of genes regulating Drosophila metabolism.Scientific reports · 2024Article
- Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration.PLoS computational biology · 2023Article
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.G3 (Bethesda, Md.) · 2021Article
- Identification of Genes Contributing to a Long Circadian Period inJournal of biological rhythms · 2021Article
- GnRH-Related Neurohormones in the Fruit FlyInternational journal of molecular sciences · 2021Review
- DNMT3.1 controls trade-offs between growth, reproduction, and life span under starved conditions in Daphnia magna.Scientific reports · 2021Article
- Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.Molecular ecology · 2021Article
- The Resistance ofAntioxidants (Basel, Switzerland) · 2020Article
- Limited influence of the microbiome on the transcriptional profile of female Aedes aegypti mosquitoes.Scientific reports · 2020Article
- Article
- Does gene flow aggravate or alleviate maladaptation to environmental stress in small populations?Evolutionary applications · 2019Article
- Dissection of Complex, Fitness-Related Traits in MultipleGenetics · 2019Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- Triacylglycerol Metabolism inGenetics · 2018Review
- Effect of Larval Nutrition on Maternal mRNA Contribution to theG3 (Bethesda, Md.) · 2018Article
- Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila.BMC genomics · 2018Article
- Regulation of Drosophila Lifespan by bellwether Promoter Alleles.Scientific reports · 2017Article
- Transcriptome Sequencing Reveals Large-Scale Changes in Axenic Aedes aegypti Larvae.PLoS neglected tropical diseases · 2017Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA major challenge of modern biology is to understand the networks of interacting genes regulating complex traits, and the subset of these genes that affect naturally occurring quantitative genetic variation. Previously, we used P-element mutagenesis and quantitative trait locus (QTL) mapping in Drosophila to identify candidate genes affecting resistance to starvation stress, and variation in resistance to starvation stress between the Oregon-R (Ore) and 2b strains. Here, we tested the efficacy of whole-genome transcriptional profiling for identifying genes affecting starvation stress resistance.
resultsWe evaluated whole-genome transcript abundance for males and females of Ore, 2b, and four recombinant inbred lines derived from them, under control and starved conditions. There were significant differences in transcript abundance between the sexes for nearly 50% of the genome, while the transcriptional response to starvation stress involved approximately 25% of the genome. Nearly 50% of P-element insertions in 160 genes with altered transcript abundance during starvation stress had mutational effects on starvation tolerance. Approximately 5% of the genome exhibited genetic variation in transcript abundance, which was largely attributable to regulation by unlinked genes. Genes exhibiting variation in transcript abundance among lines did not cluster within starvation resistance QTLs, and none of the candidate genes affecting variation in starvation resistance between Ore and 2b exhibited significant differences in transcript abundance between lines.
conclusionsExpression profiling is a powerful method for identifying networks of pleiotropic genes regulating complex traits, but the relationship between variation in transcript abundance among lines used to map QTLs and genes affecting variation in quantitative traits is complicated.
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