Evidence map›Paper›PMID 15831922›Full record

SynthesisGut2005

Epidemiology of gastro-oesophageal reflux disease: a systematic review.

J Dent, H B El-Serag, M-A Wallander, S Johansson

6 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 575 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
575citing papers in PubMed, 8 pooled it
37.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01574573 naterminatednot on this mapstarted 2009, after this paper: background citation

Impact of Weight Loss on Gastroesophageal Reflux Disease in Overweight and Obese Subjects: a Prospective Study

TypeinterventionalSponsorMidwest Biomedical ResearchRan2009 to 2017Enrolled52ConditionsGERD, ObesityArmsSelf support, group sessions
NCT02081404 nacompletednot on this mapstarted 2009, after this paper: background citation

Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study

TypeinterventionalSponsorMidwest Biomedical ResearchRan2009 to 2020Enrolled98ConditionsNon-erosive Reflux DiseaseArmsEsomeprazole, Placebo
NCT02425553 completednot on this mapstarted 2015, after this paper: background citation

Effects of Diet and Alcohol on Fullness, Reflux and Dyspeptic Symptoms After Meals

TypeobservationalSponsorUniversity of ZurichRan2015 to 2015Enrolled84ConditionsGastroesophageal Reflux, DyspepsiaArmsDiet
NCT02587910 phase2 / phase3unknown statusnot on this mapstarted 2015, after this paper: background citation

Melanole, a Nigella Sativa (Black Seed) Extract for the Treatment of Gastroesophageal Reflux Disease

TypeinterventionalSponsorLebanese American UniversityRan2015 to 2016Enrolled170ConditionsGERDArmsMelanole for GERD treatment, Placebo
NCT02755753 phase4completednot on this mapstarted 2014, after this paper: background citation

A Multicenter, Randomized, Double-blinded, Placebo-controlled Pilot Study to Evaluate the Efficacy and Safety of Rebamipide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis (REPAIR)

TypeinterventionalSponsorYongChan LeeRan2014 to 2016Enrolled143ConditionsGastroesophageal RefluxArmsLansoprazole, Rebamipide, Rebamipide-placebo
NCT05050188 phase1completednot on this mapstarted 2021, after this paper: background citation

A Phase I, Randomized, Double-blind, Placebo- and Positive-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics/Pharmacodynamics (PK/PD) of Multiple Oral Doses of H008 (Carenoprazan Hydrochloride Tablets) in Healthy Volunteers

TypeinterventionalSponsorJiangsu Carephar Pharmaceutical Co., Ltd.Ran2021 to 2021Enrolled24ConditionsErosive EsophagitisArmsH008, H008 placebo, Lansoprazole
3 · Its place in the literature

Who cites it

575 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,881 citations in OpenAlex.

  1. Pooled it
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  6. Guideline on screening for esophageal adenocarcinoma in patients with chronic gastroesophageal reflux disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
    Guideline
  7. Pooled it
  8. Approach to gastroenterological diseases in primary care.Acta bio-medica : Atenei Parmensis · 2018
    Pooled it
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  12. Is the Addition of Sublingual Melatonin to Omeprazole Superior to Omeprazole Alone in the Management of Gastroesophageal Reflux Disease Symptoms: A Clinical Trial.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Trial
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515 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J DentDepartment of Gastroenterology, Hepatology, and General Medicine, Level 7, North Wing, North Terrace, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia. jdent@mail.rah.sa.gov.au
H B El-Serag
M-A Wallander
S Johansson
Royal Adelaide Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic review of the epidemiology of gastro-oesophageal reflux disease (GORD) has been performed, applying strict criteria for quality of studies and the disease definition used. The prevalence and incidence of GORD was estimated from 15 studies which defined GORD as at least weekly heartburn and/or acid regurgitation and met criteria concerning sample size, response rate, and recall period. Data on factors associated with GORD were also evaluated. An approximate prevalence of 10-20% was identified for GORD, defined by at least weekly heartburn and/or acid regurgitation in the Western world while in Asia this was lower, at less than 5%. The incidence in the Western world was approximately 5 per 1000 person years. A number of potential risk factors (for example, an immediate family history and obesity) and comorbidities (for example, respiratory diseases and chest pain) associated with GORD were identified. Data reported in this systematic review can be interpreted with confidence as reflecting the epidemiology of "true" GORD. The disease is more common in the Western world than in Asia, and the low rate of incidence relative to prevalence reflects its chronicity. The small number of studies eligible for inclusion in this review highlights the need for global consensus on a symptom based definition of GORD.

Indexed as

AdultAgedAsiaEuropeFemaleGastroesophageal RefluxHumansIncidenceMaleMiddle AgedNorth AmericaPrevalenceRisk Factors

Identifiers

PMID15831922
PMCPMC1774487
OpenAlexW2099999179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.