ArticleGut2005
Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of occult hepatitis B and C in Africa: A systematic review and meta-analysis.Journal of infection and public health · 2022Pooled it
- HCV Ab titer and ALT level indicate occult hepatitis C virus infection in treatment-naive HCV Ab-positive and HCV Ab-negative patients: a 3-year prospective cohort study.Microbiology spectrum · 2025Article
- Molecular Analysis and Ex Vivo Infectivity of Seronegative Occult Hepatitis C Virus: A Study in Single Haemodialysis Centre.The Malaysian journal of medical sciences : MJMS · 2024Article
- Activation of the CaViruses · 2022Article
- Occult Infection with Hepatitis C Virus: Looking for Clear-Cut Boundaries and Methodological Consensus.Journal of clinical medicine · 2021Review
- Hepatitis E Virus Persistence and/or Replication in the Peripheral Blood Mononuclear Cells of Acute HEV-Infected Patients.Frontiers in microbiology · 2021Article
- Viral Interference Between Dengue Virus and Hepatitis C Virus Infections.Open forum infectious diseases · 2020Article
- Various miRNAs compensate the role of miR-122 on HCV replication.PLoS pathogens · 2020Article
- Evaluation of hepatitis C viral RNA persistence in HIV-infected patients with long-term sustained virological response by droplet digital PCR.Scientific reports · 2019Article
- High prevalence of occult hepatitis C infection in predialysis patients.World journal of hepatology · 2019Article
- Occult Hepatitis C Virus Infection: A Review.Journal of clinical and translational hepatology · 2018Review
- Prevalence of occult hepatitis C virus among hemodialysis patients in Tanta university hospitals: a single-center study.Environmental science and pollution research international · 2018Article
- The Correlation between miR-122 and Lipoprotein Lipase Expression in Chronic Hepatitis C Patients.Canadian journal of gastroenterology & hepatology · 2018Article
- Characterization of miR-122-independent propagation of HCV.PLoS pathogens · 2017Article
- Increased Spontaneous Programmed Cell Death Is Associated with Impaired Cytokine Secretion in Peripheral Blood Mononuclear Cells from Hepatitis C Virus-Positive Patients.Viral immunology · 2017Article
- Extra-hepatic infection of hepatitis C virus in the colon tissue and its relationship with hepatitis C virus pathogenesis.Journal of medical microbiology · 2016Article
- Hepatitis C Virus, Insulin Resistance, and Steatosis.Journal of clinical and translational hepatology · 2016Review
- Analysis of mutations in the core and NS5A genes of hepatitis C virus in non-responder and relapser patients after treatment with Peg-IFN-α and ribavirin.Virusdisease · 2016Article
- Hepatitis C virus: A time for decisions. Who should be treated and when?World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Occult HCV Infection: The Current State of Knowledge.Iranian Red Crescent medical journal · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOccult hepatitis C virus (HCV) infection is characterised by the presence of HCV-RNA in the liver in the absence of anti-HCV, and serum viral RNA. Up to 70% of these patients also have HCV-RNA in peripheral blood mononuclear cells (PBMC) but it is not known if HCV is replicating in these cells.
aimWe studied possible HCV replication in PBMC of 18 patients with an occult HCV infection who were selected on the basis of HCV-RNA positivity in PBMC.
methodsDetection of HCV-RNA positive and negative strands in PBMC was done by strand specific reverse transcriptase-polymerase chain reaction (RT-PCR) and by in situ hybridisation.
resultsThe presence of HCV-RNA positive strand in PBMC was confirmed in all patients by strand specific RT-PCR and by in situ hybridisation. Mean percentage of PBMC which had the HCV-RNA positive strand was 3.3% (95% confidence interval (CI) 2.1-4.4) The HCV-RNA negative strand was found in the PBMC of 11/18 (61%) patients by strand specific RT-PCR and confirmed by in situ hybridisation, and the percentage of PBMC harbouring the HCV-RNA negative strand was 3.1% (95% CI 0.8-5.5). There was a significant correlation (p = 0.001, r = 0.84) between the percentage of PBMC with the HCV-RNA positive strand and that of PBMC with the HCV-RNA negative strand.
conclusionHCV replicates in the PBMC of patients with occult HCV infection and thus, although these patients do not have serum HCV-RNA, they could be potentially infectious.
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Registered trials
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