ReviewClinical microbiology reviews2005
Melioidosis: epidemiology, pathophysiology, and management.
Review in Clinical microbiology reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 769 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
769 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,448 citations in OpenAlex.
- Whole Genome Sequencing and Comparative Genomics of the Emerging PathogenPathogens (Basel, Switzerland) · 2025Pooled it
- Diagnostic accuracy of non-culture methods for the diagnosis of melioidosis: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Brought with the wind: A case of melioidosis acquired in the United States presenting with multiple pulmonary nodules.PLoS neglected tropical diseases · 2026Article
- Melioidosis in dogs and cats: 18 cases.Journal of veterinary internal medicine · 2026Article
- Prostate abscess in tropical northern Australia: drainage strategies and outcomes.International urology and nephrology · 2026Article
- Successful treatment of pulmonary melioidosis in an Australian dog.Australian veterinary journal · 2026Article
- Melioidosis in companion animals: Analysis of 45 Australian cases (24 dogs; 21 cats) from 1997 to 2025 and a brief review of the animal and human literature.Australian veterinary journal · 2026Review
- Development and evaluation of a multiplex PCR for simultaneous detection of Mycobacterium tuberculosis complex, Mycobacterium avium complex, and Burkholderia pseudomallei in clinical specimens.PLoS neglected tropical diseases · 2026Article
- Outer membrane engineering through lipid A modification allows modulation ofInfection and immunity · 2026Article
- An Extraordinary Wet Season and a Surge of Melioidosis: A Retrospective Case Series From a Tropical Emergency Department.Emergency medicine Australasia : EMA · 2026Article
- Characterization of an isogenicInfection and immunity · 2026Article
- Global research trends, knowledge structure, and future directions in melioidosis research: a bibliometric analysis, 1990-2025.Tropical medicine and health · 2026Article
- Development and international multicenter evaluation of a second-generation immunochromatography test for the serological diagnosis of melioidosis.PLoS neglected tropical diseases · 2026Article
- Human infections caused by pathogenic Burkholderia: current clinical challenges and future perspectives.Infection · 2026Review
- Hospital-Based Cross-Sectional Study ofGeoHealth · 2026Article
- Melioidosis: diverse clinical manifestations and patient outcomes in a case series.BMC infectious diseases · 2026Review
- Current Melioidosis Diagnostic Landscape and Missed Opportunities in Biomarker Development.Diagnostics (Basel, Switzerland) · 2026Review
- Drug screening to identify compounds to eliminateiScience · 2026Article
- Article
- A hidden culprit: Unusual thyroid involvement in melioidosis-A case report.Infectious diseases & immunity · 2026Article
709 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedDosage error in article text
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melioidosis, caused by the gram-negative saprophyte Burkholderia pseudomallei, is a disease of public health importance in southeast Asia and northern Australia that is associated with high case-fatality rates in animals and humans. It has the potential for epidemic spread to areas where it is not endemic, and sporadic case reports elsewhere in the world suggest that as-yet-unrecognized foci of infection may exist. Environmental determinants of this infection, apart from a close association with rainfall, are yet to be elucidated. The sequencing of the genome of a strain of B. pseudomallei has recently been completed and will help in the further identification of virulence factors. The presence of specific risk factors for infection, such as diabetes, suggests that functional neutrophil defects are important in the pathogenesis of melioidosis; other studies have defined virulence factors (including a type III secretion system) that allow evasion of killing mechanisms by phagocytes. There is a possible role for cell-mediated immunity, but repeated environmental exposure does not elicit protective humoral or cellular immunity. A vaccine is under development, but economic constraints may make vaccination an unrealistic option for many regions of endemicity. Disease manifestations are protean, and no inexpensive, practical, and accurate rapid diagnostic tests are commercially available; diagnosis relies on culture of the organism. Despite the introduction of ceftazidime- and carbapenem-based intravenous treatments, melioidosis is still associated with a significant mortality attributable to severe sepsis and its complications. A long course of oral eradication therapy is required to prevent relapse. Studies exploring the role of preventative measures, earlier clinical identification, and better management of severe sepsis are required to reduce the burden of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.