ArticleProceedings of the National Academy of Sciences of the United States of America2005
Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network.Journal of cell science · 2024Article
- Phosphorylation status of a conserved residue in the adenylate cyclase ofFrontiers in microbiology · 2023Article
- A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.Cellular signalling · 2019Article
- Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition inFrontiers in microbiology · 2019Article
- Ras signalling in pathogenic yeasts.Microbial cell (Graz, Austria) · 2017Review
- Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.Cellular signalling · 2017Article
- cAMP Signaling Regulates Synchronised Growth of SymbioticFrontiers in plant science · 2016Article
- Article
- Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: phenotypic and molecular characterization.The Journal of clinical endocrinology and metabolism · 2014Article
- Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.The Journal of biological chemistry · 2014Article
- Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.Eukaryotic cell · 2014Article
- Fungal adenylyl cyclase acts as a signal sensor and integrator and plays a central role in interaction with bacteria.PLoS pathogens · 2013Review
- Use of a ura5+-lys7+ cassette to construct unmarked gene knock-ins in Schizosaccharomyces pombe.Current genetics · 2012Article
- Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi.PloS one · 2010Article
- Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.Eukaryotic cell · 2010Article
- Article
- Heterotrimeric G-protein subunit function in Candida albicans: both the alpha and beta subunits of the pheromone response G protein are required for mating.Eukaryotic cell · 2008Article
- Article
- Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases.Journal of biomolecular screening · 2008Article
- The cAMP pathway is important for controlling the morphological switch to the pathogenic yeast form of Paracoccidioides brasiliensis.Molecular microbiology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
G protein-mediated signaling is implicated in yeast and fungal cAMP pathways. By two-hybrid screens and pull-down experiments, we show that the fission yeast Gpa2 Galpha binds an N-terminal domain of adenylate cyclase, comprising a moderately conserved sequence within a region otherwise poorly related to other fungal adenylate cyclases. Overexpressing this domain in yeast perturbs cAMP signaling, which is restored by Gpa2 coexpression. Mutations affecting this domain, over 1,100 residues from the catalytic domain, alter glucose-triggered cAMP signaling. This is evidence for direct activation of adenylate cyclase by a fungal G protein and suggests a distinct activation mechanism from that of mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.