Trial reportThe Journal of physiology2005
Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions.
Trial report in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 6 syntheses or guidelines pooled it, 226 citations in OpenAlex.
- Effects of antidepressant administration on physical performance and perceived exertion in athletes: systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Effect of Pre-Exercise Caffeine Intake on Endurance Performance and Core Temperature Regulation During Exercise in the Heat: A Systematic Review with Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Psychiatric medication and physical performance parameters - Are there implications for treatment?Frontiers in psychiatry · 2022Pooled it
- The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- National Athletic Trainers' Association Position Statement: Exertional Heat Illnesses.Journal of athletic training · 2015Guideline
- Sport psychiatry: a systematic review of diagnosis and medical treatment of mental illness in athletes.Sports medicine (Auckland, N.Z.) · 2010Pooled it
- Dietary berberine supplementation improves select physiological and psychological responses during exertional heat stress: A pilot study in young adults.Physiological reports · 2026Trial
- Managing fatigue with methylphenidate and physical activity during cancer immunotherapy treatment.Palliative & supportive care · 2025Trial
- Timed consumption of a New Zealand blackcurrant juice support positive affective responses during a self-motivated moderate walking exercise in healthy sedentary adults.Journal of the International Society of Sports Nutrition · 2019Trial
- Oral L-menthol reduces thermal sensation, increases work-rate and extends time to exhaustion, in the heat at a fixed rating of perceived exertion.European journal of applied physiology · 2017Trial
- Fatigue-related impairments in oculomotor control are prevented by norepinephrine-dopamine reuptake inhibition.Scientific reports · 2017Trial
- Fatigue related impairments in oculomotor control are prevented by caffeine.Scientific reports · 2016Trial
- Effects of negative air ions on oxygen uptake kinetics, recovery and performance in exercise: a randomized, double-blinded study.International journal of biometeorology · 2014Trial
- The influence of acetaminophen on repeated sprint cycling performance.European journal of applied physiology · 2014Trial
- Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heat.European journal of applied physiology · 2013Trial
- Peripheral markers of central fatigue in trained and untrained during uncompensable heat stress.European journal of applied physiology · 2012Trial
- No effect of caffeine on exercise performance in high ambient temperature.European journal of applied physiology · 2011Trial
- Oral tyrosine supplementation improves exercise capacity in the heat.European journal of applied physiology · 2011Trial
- Effect of ambient temperature on caffeine ergogenicity during endurance exercise.European journal of applied physiology · 2011Trial
- The rate of heat storage mediates an anticipatory reduction in exercise intensity during cycling at a fixed rating of perceived exertion.The Journal of physiology · 2006Trial
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nine healthy endurance-trained males were recruited to examine the effect of a dual dopamine/noradrenaline reuptake inhibitor on performance, thermoregulation and the hormonal responses to exercise. Subjects performed four trials, ingesting either a placebo (pla) or 2 x 300 mg bupropion (bup), prior to exercise in temperate (18 degrees C) or warm (30 degrees C) conditions. Trials consisted of 60 min cycle exercise at 55% W(max) immediately followed by a time trial (TT). TT performance in the heat was significantly improved by bupropion (pla: 39.8 +/- 3.9 min, bup: 36.4 +/- 5.7 min; P = 0.046), but no difference between treatments was apparent in temperate conditions (pla: 30.6 +/- 2.2 min, bup: 30.6 +/- 1.9 min; P = 0.954). While TT power output was consistently lower in the heat when compared to temperate conditions, this decrement was attenuated by bupropion. At the end of the TT in the heat, both core temperature (pla 39.7 +/- 0.3 degrees C, bup 40.0 +/- 0.3 degrees C; P = 0.017) and HR (pla 178 +/- 7 beats min(-1), bup 183 +/- 12 beats min(-1); P = 0.039), were higher in the bupropion trial than in the placebo. Circulating pituitary and adrenal hormone concentrations increased throughout exercise in all trials. Circulating serum prolactin was elevated above temperate levels during exercise in a warm environment (P < 0.001). These data indicate that performance in warm conditions is enhanced by acute administration of a dual dopamine/noradrenaline reuptake inhibitor. No such effect was apparent under temperate conditions. It appears that bupropion enabled subjects to maintain a greater TT power output in the heat with the same perception of effort and thermal stress reported during the placebo trial, despite the attainment of a higher core temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.