ArticleMolecular and cellular biology2005
Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Correlation of the expression of YY1 and Fas cell surface death receptor with apoptosis of peripheral blood mononuclear cells, and the development of multiple organ dysfunction in children with sepsis.Molecular medicine reports · 2017Trial
- Aptamer-functionalized apoptotic vesicles ameliorate osteoarthritis via resuming mitochondria OXPHOS of chondrocytes.Science advances · 2026Article
- Yin Yang 1: Role in Leishmaniasis.Cells · 2025Review
- SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.PLoS pathogens · 2025Article
- Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025Review
- Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy.Nature communications · 2024Article
- YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6.Journal for immunotherapy of cancer · 2023Article
- YY1 promotes pancreatic cancer cell proliferation by enhancing mitochondrial respiration.Cancer cell international · 2022Article
- Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance ofNeural regeneration research · 2019Article
- The Two Sides of YY1 in Cancer: A Friend and a Foe.Frontiers in oncology · 2019Review
- Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Conserved RNA binding activity of a Yin-Yang 1 homologue in the ova of the purple sea urchin Strongylocentrotus purpuratus.Scientific reports · 2018Article
- CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis.International journal of cancer · 2018Article
- Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma.Biomarker research · 2018Article
- Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation.Journal of molecular cell biology · 2016Article
- Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.Scientific reports · 2016Article
- Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression.PloS one · 2015Article
- Function of YY1 in Long-Distance DNA Interactions.Frontiers in immunology · 2014Review
- Cleavage of the JunB transcription factor by caspases generates a carboxyl-terminal fragment that inhibits activator protein-1 transcriptional activity.The Journal of biological chemistry · 2013Article
- The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.Cell death and differentiation · 2012Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional regulator Yin Yang 1 (YY1) controls many aspects of cell behavior and is essential for development. We analyzed the fate of YY1 during apoptosis and studied the functional consequences. We observed that this factor is rapidly translocated into the cell nucleus in response to various apoptotic stimuli, including activation of Fas, stimulation by tumor necrosis factor, and staurosporine and etoposide treatment. Furthermore, YY1 is cleaved by caspases in vitro and in vivo at two distinct sites, IATD(12)G and DDSD(119)G, resulting in the deletion of the first 119 amino acids early in the apoptotic process. This activity generates an N-terminally truncated YY1 fragment (YY1Delta119) that has lost its transactivation domain but retains its DNA binding domain. Indeed, YY1Delta119 is no longer able to stimulate gene transcription but interacts with DNA. YY1Delta119 but not the wild-type protein or the caspase-resistant mutant YY1D12A/D119A enhances Fas-induced apoptosis, suggesting that YY1 is involved in a positive feedback loop during apoptosis. Our findings provide evidence for a new mode of regulation of YY1 and define a novel aspect of the involvement of YY1 in the apoptotic process.
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Registered trials
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