ArticleMolecular and cellular biology2005
The Mcp element from the bithorax complex contains an insulator that is capable of pairwise interactions and can facilitate enhancer-promoter communication.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 94 citations in OpenAlex.
- Su(Hw) interacts with Combgap to establish long-range chromatin contacts.Epigenetics & chromatin · 2024Article
- Polycomb Recruiters Inside and Outside of the Repressed Domains.International journal of molecular sciences · 2023Review
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Comparative interactome analysis of the PRE DNA-binding factors: purification of the Combgap-, Zeste-, Psq-, and Adf1-associated proteins.Cellular and molecular life sciences : CMLS · 2022Article
- Boundaries potentiate polycomb response element-mediated silencing.BMC biology · 2021Article
- Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems.Doklady. Biochemistry and biophysics · 2019Article
- Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.PLoS genetics · 2018Article
- Review
- Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters.World journal of biological chemistry · 2016Review
- Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.PLoS genetics · 2016Article
- Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Genetics · 2016Article
- The boundary paradox in the Bithorax complex.Mechanisms of development · 2015Article
- Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture.Genes · 2015Review
- The open for business model of the bithorax complex in Drosophila.Chromosoma · 2015Review
- Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.BMC biology · 2015Article
- Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin.Genome research · 2015Article
- Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.Epigenetics · 2014Article
- Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Mechanisms and proteins involved in long-distance interactions.Frontiers in genetics · 2014Review
- The border between the ultrabithorax and abdominal-A regulatory domains in the Drosophila bithorax complex.Genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin insulators, or boundary elements, appear to control eukaryotic gene expression by regulating interactions between enhancers and promoters. Boundaries have been identified in the 3' cis-regulatory region of Abd-B, which is subdivided into a series of separate iab domains. Boundary elements such as Mcp, Fab-7, and Fab-8 and adjacent silencers flank the iab domains and restrict the activity of the iab enhancers. We have identified an insulator in the 755-bp Mcp fragment that is linked to the previously characterized Polycomb response element (PRE) and silences the adjacent genes. This insulator blocks the enhancers of the yellow and white genes and protects them from PRE-mediated repression. The interaction between the Mcp elements, each containing the insulator and PRE, allows the eye enhancer to activate the white promoter over the repressed yellow domain. The same level of white activation was observed when the Mcp element combined with the insulator alone was interposed between the eye enhancer and the promoter, suggesting that the insulator is responsible for the interaction between the Mcp elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.