ArticleMolecular and cellular biology2005
The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Wnt signaling regulates chemokine production and cell migration of circulating human monocytes.Cell communication and signaling : CCS · 2024Article
- Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies.Oncology research · 2021Review
- An Autocrine Wnt5a Loop Promotes NF-κB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma.Cells · 2019Article
- Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways.FEBS letters · 2017Article
- Canonical Wnt signaling in diabetic retinopathy.Vision research · 2017Review
- Article
- MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling.Journal of cellular physiology · 2017Article
- Concurrent Hypermethylation ofMolecules and cells · 2017Article
- Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation.Stem cells international · 2017Article
- Effect of Wnt3a on keratinocytes utilizing in vitro and bioinformatics analysis.International journal of molecular sciences · 2014Article
- Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.PloS one · 2014Article
- Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.BMC cancer · 2013Article
- Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.The Biochemical journal · 2012Article
- NMDA receptor activation stimulates transcription-independent rapid wnt5a protein synthesis via the MAPK signaling pathway.Molecular brain · 2012Article
- Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases.The Prostate · 2011Article
- Integrative analyses of conserved WNT clusters and their co-operative behaviour in human breast cancer.Bioinformation · 2011Article
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.Genes & development · 2010Article
- Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.Genes & development · 2010Article
- Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.Cancer cell · 2010Article
- Evidence for altered Wnt signaling in psoriatic skin.The Journal of investigative dermatology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Wnt glycoproteins are developmentally essential signaling molecules, and lesions afflicting Wnt pathways play important roles in human diseases. Some Wnts signal to the canonical pathway by stabilizing beta-catenin, while others lack this activity. Frizzled serpentine receptors mediate distinct signaling pathways by both classes of Wnts. Here, we tandemly linked noncanonical Wnt5a with the C-terminal half of Dickkopf-2 (Dkk2C), a distinct ligand of the Wnt coreceptor LRP5/6. Whereas Wnt5a, Dkk2C, or both together were incapable of stimulating endogenous canonical signaling, the Wnt5a/Dkk2C chimera efficiently activated this pathway in a manner inhibitable by specific antagonists of either frizzled or LRP receptors. Thus, activation of the canonical pathway requires ligand coupling of an endogenous frizzled/LRP coreceptor complex, rather than Wnt triggering each receptor independently. Moreover, fusion of Wnt5a with Dkk2C unmasked its ability to signal to Dishevelled through multiple frizzleds, indicating that the lack of functional interaction with LRP distinguishes noncanonical Wnt5a from canonical Wnts in mammalian cells. These findings provide a novel mechanism by which the same receptor can be switched between distinct signaling pathways depending on the differential recruitment of a coreceptor by members of the same ligand family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.