ArticleMolecular and cellular biology2005
Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Connecting Hippo Pathway and Cytoophidia inInternational journal of molecular sciences · 2024Article
- Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.EMBO reports · 2024Article
- Review
- MYC: there is more to it than cancer.Frontiers in cell and developmental biology · 2024Review
- A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration.Disease models & mechanisms · 2023Article
- NOC1 is a direct MYC target, and its protein interactome dissects its activity in controlling nucleolar function.Frontiers in cell and developmental biology · 2023Article
- Multiplexed functional genomic analysis of 5' untranslated region mutations across the spectrum of prostate cancer.Nature communications · 2021Observational
- Myc as a Regulator of Ribosome Biogenesis and Cell Competition: A Link to Cancer.International journal of molecular sciences · 2020Review
- Article
- Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma.BMC cancer · 2019Article
- Review
- PAF1 complex component Leo1 helps recruitProceedings of the National Academy of Sciences of the United States of America · 2017Article
- dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.PLoS genetics · 2017Article
- The Interplay between Myc and CTP Synthase in Drosophila.PLoS genetics · 2016Article
- Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila.Scientific reports · 2015Article
- Drosophila Myc: A master regulator of cellular performance.Biochimica et biophysica acta · 2015Review
- snoRNAs are a novel class of biologically relevant Myc targets.BMC biology · 2015Article
- Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation.Bioscience reports · 2014Review
- Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts.Molecular and cellular biology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myc is a transcription factor with diverse biological effects ranging from the control of cellular proliferation and growth to the induction of apoptosis. Here we present a comprehensive analysis of the transcriptional targets of the sole Myc ortholog in Drosophila melanogaster, dMyc. We show that the genes that are down-regulated in response to dmyc inhibition are largely identical to those that are up-regulated after dMyc overexpression and that many of them play a role in growth control. The promoter regions of these targets are characterized by the presence of the E-box sequence CACGTG, a known dMyc binding site. Surprisingly, a large subgroup of (functionally related) dMyc targets contains a single E-box located within the first 100 nucleotides after the transcription start site. The relevance of this E-box and its position was confirmed by a mutational analysis of a selected dMyc target and by the observation of its evolutionary conservation in a different Drosophila species, Drosophila pseudoobscura. These observations raise the possibility that a subset of Myc targets share a distinct regulatory mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.