ArticleEnvironmental health : a global access science source2005
Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study.
Article in Environmental health : a global access science source, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis.Jornal de pediatriaPooled it
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- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Association between blood heavy metal element and all-cause mortality in asthmatic adults: a cohort study.Scientific reports · 2024Article
- Multiple prenatal exposures and acute-care clinical encounters for asthma among children born to mothers living near a Superfund site.American journal of epidemiology · 2024Article
- Review
- Current knowledge on the effects of environmental contaminants in early life nutrition.Frontiers in nutrition · 2023Review
- Immune Responses to COVID-19 Vaccines in Patients with Chronic Kidney Disease and Lead Exposure.International journal of molecular sciences · 2022Article
- Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures.Current environmental health reports · 2022Review
- Exposure to DDT from indoor residual spraying and biomarkers of inflammation among reproductive-aged women from South Africa.Environmental research · 2020Article
- Environmental Lead Exposure and Influenza and Respiratory Syncytial Virus Diagnoses in Young Children: A Test-Negative Case-Control Study.International journal of environmental research and public health · 2020Article
- Cytomegalovirus seroprevalence, recurrence, and antibody levels: Associations with cadmium and lead exposures in the general United States population.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study.Environmental health : a global access science source · 2020Article
- Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children.International journal of environmental research and public health · 2019Article
- Body Burden of Dichlorodiphenyl Dichloroethene (DDE) and Childhood Pulmonary Function.International journal of environmental research and public health · 2017Article
- In utero exposure to DDT and incidence of diarrhea among boys from tropical Mexico.Environmental research · 2017Article
- Lead exposure, IgE, and the risk of asthma in children.Journal of exposure science & environmental epidemiology · 2017Article
- Maternal exposure to metals and persistent pollutants and cord blood immune system biomarkers.Environmental health : a global access science source · 2015Article
- Relationship between urine dichlorophenol levels and asthma morbidity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent organochlorines and lead (Pb) have been shown to have immunomodulating properties. Children are at greater risk for exposure to these environmental toxicants, but very little data exist on simultaneous exposures to these substances.
methodsWe investigated whether the organochlorine compounds (OC) dichlorodiphenylethylene (DDE), hexachlorobenzene (HCB), hexachlorocyclohexane (gamma-HCH), the sum of polychlorinated biphenyls (SigmaPCBs) and Pb were associated with immune markers such as immunoglobulin (Ig) levels, white blood cell (WBC), counts of lymphocytes; eosinophils and their eosinophilic granula as well as IgE count on basophils. The investigation was part of a cross-sectional environmental study in Hesse, Germany. In 1995, exposure to OC and Pb were determined, questionnaire data collected and immune markers quantified in 331 children. For the analyses, exposure (OC and Pb) concentrations were grouped in quartiles (gamma-HCH into tertiles). Using linear regression, controlling for age, gender, passive smoking, serum lipids, and infections in the previous 12 months, we assessed the association between exposures and immune markers. Adjusted geometric means are provided for the different exposure levels.
resultsGeometric means were: DDE 0.32 microg/L, SigmaPCBs 0.50 microg/L, HCB 0.22 microg/L, gamma-HCH 0.02 microg/L and Pb 26.8 microg/L. The SigmaPCBs was significantly associated with increased IgM levels, whereas HCB was inversely related to IgM. There was a higher number of NK cells (CD56+) with increased gamma-HCH concentrations. At higher lead concentrations we saw increased IgE levels. DDE showed the most associations with significant increases in WBC count, in IgE count on basophils, IgE, IgG, and IgA levels. DDE was also found to significantly decrease eosinophilic granula content.
conclusionLow-level exposures to OC and lead (Pb) in children may have immunomodulating effects. The increased IgE levels, IgE count on basophils, and the reduction of eosinophilic granula at higher DDE concentrations showed a most consistent pattern, which could be of clinical importance in the etiology of allergic diseases.
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