ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Migrainous Infarction and Cortical Spreading Depression.Discoveries (Craiova, Romania) · 2020Review
- Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.Current neuropharmacology · 2019Review
- An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2018Review
- Intranasally administered IGF-1 inhibits spreading depression in vivo.Brain research · 2017Article
- The genetic relationship between epilepsy and hemiplegic migraine.Neuropsychiatric disease and treatment · 2017Review
- Spreading depression transiently disrupts myelin via interferon-gamma signaling.Experimental neurology · 2015Article
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- Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress.Journal of neurochemistry · 2012Article
- Pregnant serum induces neuroinflammation and seizure activity via TNFα.Experimental neurology · 2012Article
- Modeling neural immune signaling of episodic and chronic migraine using spreading depression in vitro.Journal of visualized experiments : JoVE · 2011Article
- Spreading depression sends microglia on Lévy flights.PloS one · 2011Article
- Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- Cold pre-conditioning neuroprotection depends on TNF-α and is enhanced by blockade of interleukin-11.Journal of neurochemistry · 2011Article
- Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- Strategies for study of neuroprotection from cold-preconditioning.Journal of visualized experiments : JoVE · 2010Article
- Neuronostatin is co-expressed with somatostatin and mobilizes calcium in cultured rat hypothalamic neurons.Neuroscience · 2010Article
- TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine.Dose-response : a publication of International Hormesis Society · 2010Article
- Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.Journal of neuroscience research · 2009Article
- C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro.Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Spreading depression (SD) involves current flow through principal neurons, but the pattern of current flow over the expanse of susceptible tissues or individual principal neurons remains undefined. Accordingly, tissue and single cell maps made from digital imaging of voltage-sensitive dye changes in hippocampal organotypic cultures undergoing SD were processed via optical current source density analysis to reveal the currents associated with pyramidal neurons. Two distinctive current flow patterns were seen. The first was a trilaminar pattern (420 microm2) that developed with the onset of SD in CA3 pyramidal neurons, in which SD most often began. This initial pattern comprised a somatic current sink with current sources to either side in the dendrites that lasted for seconds extending into the first aspect of the classical "inverted saddle" interstitial direct current waveform of SD. Next, the somatic sink backpropagated at a speed of millimeters per minute into the proximal dendrites, resulting in a reversal of the initial current flow pattern to its second orientation, namely dendritic sinks associated with a somatic source. The latter persisted for the remainder of SD in CA3 and was the only pattern seen in CA1, in which SD was rarely initiated. This backpropagating SD current flow resembles that of activity-dependent synaptic activation. Retrograde and associative signaling via principal neuron current flow is a key means to affect tissue function, including synaptic activation and, by extension, perhaps SD. Such current-related postsynaptic signaling might not only help explain SD but also neuroprotection and migraine, two phenomena increasingly recognized as being related to SD.
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