ArticleProceedings of the National Academy of Sciences of the United States of America2005
Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.
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Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Statistical structure of host-phage interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Pooled it
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- A colorimetric method for detecting virulent bacteriophage to Vibrio cholerae in fecal and environmental samples.PLoS neglected tropical diseases · 2025Article
- The dynamics of single stranded, positive sense RNA bacteriophages in the rumen virome.Scientific reports · 2025Article
- Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Cholera rapid diagnostic tests at the host-microbe interface: Key Considerations for Global Deployments.medRxiv : the preprint server for health sciences · 2025Article
- Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation.Nature microbiology · 2025Article
- Phage therapy for environmental biotechnology applications.Frontiers in microbiology · 2025Review
- Quorum regulated latent environmental cells of toxigenic Vibrio cholerae and their role in cholera outbreaks.Gut pathogens · 2024Review
- DdmABC-dependent death triggered by viral palindromic DNA sequences.Cell reports · 2024Article
- Phage predation, disease severity and pathogen genetic diversity in cholera patients.bioRxiv : the preprint server for biology · 2024Article
- Dynamics of CRISPR-mediated virus-host interactions in the human gut microbiome.The ISME journal · 2024Article
- Bacteriophage-Host Interactions and Coevolution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The phageome in normal and inflamed human skin.Science advances · 2023Article
- Genomic analysis ofHeliyon · 2023Article
- Development of a Monoclonal Antibody to a Vibriophage as a Proxy for Vibrio cholerae Detection.Infection and immunity · 2022Article
- The Vibrio cholerae Seventh Pandemic Islands act in tandem to defend against a circulating phage.PLoS genetics · 2022Article
- Assay for Evaluating the Abundance ofPathogens (Basel, Switzerland) · 2022Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Phage predation of Vibrio cholerae has recently been reported to be a factor that influences seasonal epidemics of cholera in Bangladesh. To understand more about this phenomenon, we studied the dynamics of the V. cholerae-phage interaction during a recent epidemic in Dhaka. Because the outbreak strain causing this epidemic was resistant to multiple antibiotics, including streptomycin, we used a selective medium containing streptomycin to monitor accurately the abundance of this strain in the environment. The changing prevalence in the environment of the epidemic V. cholerae O1 strain and a particular lytic cholera phage (JSF4) to which it was sensitive was measured every 48-72 h for 17 weeks. We also monitored the incidence of phage excretion in stools of 387 cholera patients during the epidemic. The peak of the epidemic was preceded by high V. cholerae prevalence in the environment and was followed by high JSF4 phage levels as the epidemic ended. The buildup to the phage peak in the environment coincided with increasing excretion of the same phage in the stools of cholera patients. These results suggest that patients toward the end of the epidemic ingested both JSF4 phage and the outbreak V. cholerae strain. Host-mediated phage amplification during the cholera epidemic likely contributed to increased environmental phage abundance, decreased load of environmental V. cholerae and, hence, the collapse of the epidemic. Thus, in vivo phage amplification in patients and subsequent phage predation in the environment may explain the self-limiting nature of seasonal cholera epidemics in Bangladesh.
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