ArticleMolecular biology of the cell2005
Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Cerevisterol fromFrontiers in pharmacology · 2026Article
- AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.Cell death & disease · 2024Article
- Structure and molecular basis of spermatid elongation in theOpen biology · 2023Review
- Article
- Rapid Genomic Evolution Drives the Diversification of Male Reproductive Genes in Dung Beetles.Genome biology and evolution · 2021Article
- Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.Developmental biology · 2020Article
- Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA.Cell death & disease · 2019Article
- Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation inGenetics · 2017Article
- Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesis.PLoS genetics · 2017Article
- Drosophila LKB1 is required for the assembly of the polarized actin structure that allows spermatid individualization.PloS one · 2017Article
- Functional relevance of the newly evolved sperm dynein intermediate chain multigene family in Drosophila melanogaster males.Communicative & integrative biology · 2012Article
- Drosophila sperm proteome evolution: Insights from comparative genomic approaches.Spermatogenesis · 2012Article
- Drosophila spermiogenesis: Big things come from little packages.Spermatogenesis · 2012Article
- Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The poly(A) polymerase GLD2 is required for spermatogenesis in Drosophila melanogaster.Development (Cambridge, England) · 2011Article
- Article
- Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.Scientific reports · 2011Article
- LUMP is a putative double-stranded RNA binding protein required for male fertility in Drosophila melanogaster.PloS one · 2011Article
- Conserved genes act as modifiers of invertebrate SMN loss of function defects.PLoS genetics · 2010Article
- Novel LC8 mutations have disparate effects on the assembly and stability of flagellar complexes.The Journal of biological chemistry · 2009Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Toward the end of spermiogenesis, spermatid nuclei are compacted and the clonally related spermatids individualize to become mature and active sperm. Studies in Drosophila showed that caudal end-directed movement of a microfilament-rich structure, called investment cone, expels the cytoplasmic contents of individual spermatids. F-actin dynamics plays an important role in this process. Here we report that the dynein light chain 1 (DLC1) of Drosophila is involved in two separate cellular processes during sperm individualization. It is enriched around spermatid nuclei during postelongation stages and plays an important role in the dynein-dynactin-dependent rostral retention of the nuclei during this period. In addition, DDLC1 colocalizes with dynamin along investment cones and regulates F-actin assembly at this organelle by retaining dynamin along the cones. Interestingly, we found that this process does not require the other subunits of cytoplasmic dynein-dynactin complex. Altogether, these observations suggest that DLC1 could independently regulate multiple cellular functions and established a novel role of this protein in F-actin assembly in Drosophila.
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