ArticlePediatric nephrology (Berlin, Germany)2005
Widening of foot processes in normoalbuminuric adolescents with type 1 diabetes.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases.Kidney international · 2024Article
- Cystatin C, renal resistance index, and kidney injury molecule-1 are potential early predictors of diabetic kidney disease in children with type 1 diabetes.Frontiers in pediatrics · 2022Article
- Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice.Frontiers in medicine · 2021Article
- NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus.Journal of diabetes research · 2017Article
- Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy.Journal of diabetes research · 2016Article
- Podocyte structural parameters do not predict progression to diabetic nephropathy in normoalbuminuric type 1 diabetic patients.American journal of nephrology · 2015Article
- Associations between structural and functional changes to the kidney in diabetic humans and mice.Life sciences · 2013Review
- Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease.Kidney international · 2011Article
- Podocyte number in the maturing rat kidney.American journal of nephrology · 2011Article
- The natural progression of kidney injury in young type 1 diabetic patients.Current diabetes reports · 2009Review
- Diabetes and chronic kidney disease: lessons from the Pima Indians.Pediatric nephrology (Berlin, Germany) · 2008Review
- Histopathology of diabetic nephropathy.Seminars in nephrology · 2007Review
- Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with Type 1 diabetes.Journal of diabetes and its complicationsArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We compared renal morphology in normoalbuminuric adolescents with type 1 diabetes with age-and sex-matched controls. Renal morphological measurements in 46 unselected adolescents with diabetes for approx. 10 years were compared with those in 20 healthy kidney donors. Renal volume estimated by ultra-sound, renal function determined by clearances of inulin and para-aminohippurate, and long-term mean HbA(1c) were measured in the patient group. Basement membrane thickness (BMT), mesangial matrix and capillary volume fractions per glomerulus [V(V)(matrix/glom), V(V)(cap/glom)] were significantly greater in patients than in controls (505 nm, 10.5%, 46.7% vs. 320 nm, 7.9% and 39.3%). The foot processes were wider in patients than in living donors (414 nm vs. 372 nm). There was no difference in mean kidney volume of patients with diabetes and healthy subjects. Glomerular filtration rate, body weight, and slit pore length density explained 60% of the variance in renal volume. After about 10 years' duration of type 1 diabetes, BMT, V(V)(matrix/glom), V(V)(cap/glom), and foot process width were greater in normoalbuminuric adolescents than in healthy controls. This increase in foot processes of normoalbuminuric patients has not been reported before.
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