Trial reportEuropean journal of clinical nutrition2005
The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers.
Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials.European journal of clinical nutrition · 2018Pooled it
- The effect of conjugated linoleic acid supplementation on the nutritional status of COPD patients.International journal of chronic obstructive pulmonary disease · 2016Trial
- Linoleic Acid-A Feasible Preventive Approach for Visceral Leishmaniasis.Frontiers in nutrition · 2021Article
- Plastrum Testudinis Extract Mitigates Thiram Toxicity in Broilers via Regulating PI3K/AKT Signaling.Biomolecules · 2019Article
- Atheroprotective effects of conjugated linoleic acid.British journal of clinical pharmacology · 2017Review
- Pros and cons of CLA consumption: an insight from clinical evidences.Nutrition & metabolism · 2015Review
- A comparison of supplemental calcium soap of palm fatty acids versus tallow in a corn-based finishing diet for feedlot steers.Journal of animal science and technology · 2015Article
- Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunity and inflammatory parameters in adults with active rheumatoid arthritis: a randomized controlled trial.International journal of preventive medicine · 2014Article
- Statement on the safety of the "conjugated linoleic acid (CLA) rich oils" Clarinol® and Tonalin® TG 80 as Novel Food ingredients.EFSA journal. European Food Safety Authority · 2012Article
- Conjugated linoleic acids as functional food: an insight into their health benefits.Nutrition & metabolism · 2009Article
- Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes.Nature reviews. Endocrinology · 2009Review
- Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA.Nutrition research and practice · 2008Article
- Extracts from Plastrum testudinis promote proliferation of rat bone-marrow-derived mesenchymal stem cells.Cell proliferation · 2007Article
- Trans fatty acids: effects on cardiometabolic health and implications for policy.Prostaglandins, leukotrienes, and essential fatty acidsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers.
designDouble-blind, randomised, placebo-controlled intervention trial. SUBJECTS AND
interventionA total of 55 healthy volunteers (n=20 males, n=35 females) were randomised into one of three study groups who received 3 g/day of a fatty acid blend containing a 50:50 cis-9, trans-11: trans-10, cis-12 CLA isomer blend (2 g CLA), and 80:20 cis-9, trans-11: trans-10, cis-12 (80:20) CLA isomer blend (1.76 g CLA) or linoleic acid (control, 2 g linoleic acid) for 8 weeks.
resultsSupplementation with the 80:20 CLA isomer blend significantly (P< or =0.05) enhanced PHA-induced lymphocyte proliferation. CLA decreased basal interleukin (IL)-2 secretion (P< or =0.01) and increased PHA-induced IL-2 and tumor necrosis factor alpha (TNF(alpha)) production (P< or =0.01). However, these effects were not solely attributable to CLA as similar results were observed with linoleic acid. CLA supplementation had no significant effect on peripheral blood mononuclear cells IL-4 production, or on serum-soluble intercellular adhesion molecule-1 (sICAM-1) or plasma prostaglandin E2 (PGE2) or leukotreine B4 (LTB4) concentrations.
conclusionsThis study shows that CLA supplementation had a minimal effect on the markers of human immune function. Furthermore, supplementation with CLA had no immunological benefit compared with linoleic acid.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.