Evidence map›Paper›PMID 15827553›Full record

ArticleBritish journal of cancer2005

Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening.

N W J Bulkmans, L Rozendaal, F J Voorhorst, P J F Snijders, C J L M Meijer

Abstract readEvaluation Study
In one paragraph

Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015
    Article
  10. Article
  11. Article
  12. Early cervical neoplasia: advances in screening and treatment modalities.Clinical advances in hematology & oncology : H&O · 2010
    Review
  13. Article
  14. Article
  15. Laboratory and clinical aspects of human papillomavirus testing.Critical reviews in clinical laboratory sciences
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

N W J BulkmansDepartment of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
L Rozendaal
F J Voorhorst
P J F Snijders
C J L M Meijer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We prospectively evaluated the 5-year predictive values of adding high-risk human papillomavirus (hrHPV) testing to cytology for the detection of > or = cervical intraepithelial neoplasia (CIN)3 lesions in a population-based cohort of 2810 women. At baseline, nine (0.3%) women had prevalent lesions > or = CIN3, all being hrHPV positive. After 5 years of follow-up, four (6.5%) of the 62 hrHPV-positive women with normal cytology developed lesions > or = CIN3, vs only one (0.05%) of the 2175 hrHPV-negative women with normal cytology. High-risk human papillomavirus testing or combined screening revealed a much higher sensitivity, at the cost of a small decrease in specificity, and a higher negative predictive value for the detection of lesions > or = CIN3 till the next screening round (5 years) than cytology alone.

Indexed as

FemaleHumansMass ScreeningPapillomaviridaePapillomavirus InfectionsPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical Neoplasms

Identifiers

PMID15827553
PMCPMC2362030

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.