ArticleJournal of medical genetics2005
A male-specific quantitative trait locus on 1p21 controlling human stature.
Article in Journal of medical genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PloS one · 2013Article
- Genome-wide association study identified CNP12587 region underlying height variation in Chinese females.PloS one · 2012Article
- Array-CGH and quantitative PCR genetic analysis in a case with bilateral hypoplasia of pulmonary arteries and lungs and simultaneous unilateral renal agenesis.International journal of clinical and experimental pathology · 2010Article
- Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci.International journal of obesity (2005) · 2009Article
- Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population.Human genetics · 2009Article
- Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.European journal of human genetics : EJHG · 2009Article
- A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population.The Journal of clinical endocrinology and metabolism · 2008Article
- Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.Human genetics · 2008Article
- Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.Human biology · 2008Article
- Association of the estrogen receptor 1 (ESR1) gene with body height in adult males from two Swedish population cohorts.PloS one · 2008Article
- Genome partitioning of genetic variation for height from 11,214 sibling pairs.American journal of human genetics · 2007Article
- Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.Human genetics · 2007Article
- Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.PLoS genetics · 2007Article
- Genetic linkage of human height is confirmed to 9q22 and Xq24.Human genetics · 2006Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundMany genome-wide scans aimed at complex traits have been statistically underpowered due to small sample size. Combining data from several genome-wide screens with comparable quantitative phenotype data should improve statistical power for the localisation of genomic regions contributing to these traits.
objectiveTo perform a genome-wide screen for loci affecting adult stature by combined analysis of four previously performed genome-wide scans.
methodsWe developed a web based computer tool, Cartographer, for combining genetic marker maps which positions genetic markers accurately using the July 2003 release of the human genome sequence and the deCODE genetic map. Using Cartographer, we combined the primary genotype data from four genome-wide scans and performed variance components (VC) linkage analyses for human stature on the pooled dataset of 1417 individuals from 277 families and performed VC analyses for males and females separately.
resultsWe found significant linkage to stature on 1p21 (multipoint LOD score 4.25) and suggestive linkages on 9p24 and 18q21 (multipoint LOD scores 2.57 and 2.39, respectively) in males-only analyses. We also found suggestive linkage to 4q35 and 22q13 (multipoint LOD scores 2.18 and 2.85, respectively) when we analysed both females and males and to 13q12 (multipoint LOD score 2.66) in females-only analyses.
conclusionsWe strengthened the evidence for linkage to previously reported quantitative trait loci (QTL) for stature and also found significant evidence of a novel male-specific QTL on 1p21. Further investigation of several interesting candidate genes in this region will help towards characterisation of this first sex-specific locus affecting human stature.
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