ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2005
Variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) are associated with severe forms of pulmonary tuberculosis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis.PloS one · 2011Pooled it
- Correlation analysis between SNPs in microRNA-machinery genes and tuberculosis susceptibility in the Chinese Uygur population.Medicine · 2018Article
- NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis.BioMed research international · 2016Article
- Host genome polymorphisms and tuberculosis infection: What we have to say?The Egyptian journal of chest diseases and tuberculosis · 2014Article
- Association between SNPs in microRNA-machinery genes and tuberculosis susceptibility in Chinese Tibetan population.Molecular biology reports · 2013Article
- Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.American journal of human genetics · 2013Article
- The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis.Malaysian orthopaedic journal · 2013Article
- Innate immune gene polymorphisms in tuberculosis.Infection and immunity · 2012Review
- Polymorphisms of the NRAMP1 gene: distribution and susceptibility to the development of pulmonary tuberculosis in the Greek population.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Mycobacterial cells have dual nickel-cobalt sensors: sequence relationships and metal sites of metal-responsive repressors are not congruent.The Journal of biological chemistry · 2007Article
- P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis.Clinical and experimental immunology · 2007Article
- Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients.World journal of gastroenterology · 2006Article
- An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults.The Journal of experimental medicine · 2006Article
- Progress and new directions in genetics of tuberculosis: an NHLBI working group report.American journal of respiratory and critical care medicine · 2005Article
- Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis.Lung India : official organ of Indian Chest SocietyArticle
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8 authors at 3 institutions in 3 countries.
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Abstract
Although genetic factors may affect susceptibility to tuberculosis, studies that have assessed variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) and their association with tuberculosis in humans have yielded conflicting results. It is likely that NRAMP1 polymorphisms may be associated with progression to severe forms of pulmonary tuberculosis rather than with susceptibility to Mycobacterium tuberculosis infection. To test this possibility, we examined NRAMP1 variants at the INT4 and D543N loci, as well as their association with severe forms of pulmonary tuberculosis, in 127 patients with active pulmonary tuberculosis and in 91 ethnically matched, healthy control subjects in areas of China where tuberculosis is endemic. We found that NRAMP1 polymorphisms at these 2 loci were significantly associated with 2 severe forms of pulmonary tuberculosis: sputum smear-positive tuberculosis and cavitary tuberculosis. The NRAMP1 variants were not associated with pulmonary M. tuberculosis infection, when analyses of all patients with tuberculosis and all control subjects were performed. The findings of the present study support the hypothesis that genetic variants of NRAMP1 may have an effect on bacilli growth and on outcomes of pulmonary tuberculosis, but not on susceptibility to M. tuberculosis infection.
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