SynthesisMolecular psychiatry2005
Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.
Synthesis in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Pooled it
- Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder.BMC medical genetics · 2010Pooled it
- Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.Schizophrenia research · 2008Pooled it
- Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.Schizophrenia research · 2008Pooled it
- Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients.Molecular psychiatry · 2007Pooled it
- Pooled it
- Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior.Molecular psychiatry · 2007Pooled it
- Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.PloS one · 2026Article
- Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process.Translational psychiatry · 2022Article
- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states.Brain and behavior · 2019Article
- Epidemiology and risk factors for bipolar disorder.Therapeutic advances in psychopharmacology · 2018Review
- Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study.Neuropsychiatric disease and treatment · 2016Article
- Association of Anxiety Symptoms in Offspring of Bipolar Parents with Serotonin Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype.Journal of child and adolescent psychopharmacology · 2015Article
- Article
- Serotonin transporter polymorphism is associated with increased apnea-hypopnea index in older adults.International journal of geriatric psychiatry · 2014Article
- Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study.Psychiatry journal · 2013Article
- Emotional dysfunction as a marker of bipolar disorders.Frontiers in bioscience (Elite edition) · 2012Review
- Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia.Behavioral and brain functions : BBF · 2012Article
- Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy.Pharmacogenomics and personalized medicine · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serotonin transporter (5-HTT) is a candidate gene for bipolar disorder (BPD). It has been investigated for association with the illness in a series of studies, but overall results have been inconsistent and its role in the disorder remains controversial. Systematic reviews using meta-analytical techniques are a useful method for objectively and reproducibly assessing individual studies and generating combined results. We performed two meta-analyses of published studies--both population-based and family-based studies--investigating the association between BPD and the 5-HTT gene-linked polymorphic region (5-HTTLPR) and the intron 2 variable numbers of tandem repeats (VNTR) polymorphisms. The literature was searched using Medline and Embase to identify studies for inclusion. We statistically joined population-based and family-based studies into a single meta-analysis. For both polymorphisms, our review revealed significant pooled odds ratios (ORs): 1.12 (95% CI 1.03-1.21) for the 5-HTTLPR and 1.12 (95% CI 1.02-1.22) for the intron 2 VNTR. Meta-regression showed that neither the study type (population-based vs family-based; P=0.41 for the 5-HTTLPR and P=0.91 for the intron 2 VNTR) nor the sample ethnicity (Caucasian vs non-Caucasian; P=0.35 for the 5-HTTLPR and P=0.66 for the intron 2 VNTR) significantly contributed to the heterogeneity of the meta-analyses. The observed ORs could be regarded simply as a very small but detectable effect of the 5-HTT, which has an additive effect when combined with other susceptibility loci. Alternative hypotheses on this finding were also discussed: a stronger effect of the haplotypes involving the two polymorphisms or other SNP markers; a more direct effect of these polymorphisms on specific phenotypes of BPD; and the presence of gene-environment interaction as a mediator of the genetic effects of 5-HTT.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.