ArticleThe EMBO journal1992
Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 206 citations in OpenAlex.
- IL-3: key orchestrator of inflammation.Frontiers in immunology · 2024Review
- Strategies to therapeutically modulate cytokine action.Nature reviews. Drug discovery · 2023Review
- Plasmacytoid dendritic cells during COVID-19: Ally or adversary?Cell reports · 2022Review
- The quest to slow ageing through drug discovery.Nature reviews. Drug discovery · 2020Review
- Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis.Haematologica · 2020Article
- Review
- The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.Leukemia · 2018Article
- Modeling TImmunological reviews · 2017Review
- Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases.Nature reviews. Drug discovery · 2016Review
- Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Review
- Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons.The Journal of biological chemistry · 2012Article
- The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.Genes & development · 2010Article
- The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.The Journal of biological chemistry · 2010Article
- Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.The Journal of biological chemistry · 2010Article
- Targeting eosinophils in asthma.Current molecular medicine · 2008Review
- Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.The Biochemical journal · 2002Article
- Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution.Genome research · 2001Article
- Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions.The American journal of pathology · 2001Article
- Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias.Leukemia · 2000Article
- Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human interleukin-3 receptor (IL-3R) is composed of an IL-3 specific alpha subunit (IL-3R alpha) and a common beta subunit (beta c) that is shared by IL-3, granulocyte/macrophage colony stimulating factor (GM-CSF) and IL-5 receptors. In contrast to the human, the mouse has two distinct but related genes, AIC2A and AIC2B, both of which are homologous to the human beta c gene. AIC2B has proved to encode a common beta subunit between mouse GM-CSF and IL-5 receptors. AIC2A is unique to the mouse and encodes a low affinity IL-3 binding protein. Based on the observation that the AIC2A protein is a component of a high affinity IL-3R, we searched for a cDNA encoding a protein which conferred high affinity IL-3 binding when coexpressed with the AIC2A protein in COS7 cells. We obtained such a cDNA (SUT-1) encoding a mature protein of 70 kDa that has weak homology to the human IL-3R alpha. The SUT-1 protein bound IL-3 with low affinity and formed high affinity receptors not only with the AIC2A protein but also with the AIC2B protein. Both high affinity IL-3Rs expressed on a mouse T cell line, CTLL-2, showed similar IL-3 binding properties and transmitted a growth signal in response to IL-3. Thus, the mouse has two distinct functional high affinity IL-3Rs, providing a molecular explanation for the differences observed between mouse and human IL-3Rs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.