ArticleThe EMBO journal1992
Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 124 citations in OpenAlex.
- Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo.PloS one · 2010Article
- Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.Molecular and cellular biology · 2009Article
- Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina).Journal of negative results in biomedicine · 2006Article
- Hox genes and their candidate downstream targets in the developing central nervous system.Cellular and molecular neurobiology · 2005Review
- Sequence analysis and tissue specific expression of human HOXA7.Molecular biotechnology · 2000Article
- Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.Neoplasia (New York, N.Y.) · 1999Article
- Selectivity, sharing and competitive interactions in the regulation of Hoxb genes.The EMBO journal · 1998Article
- Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.The EMBO journal · 1996Article
- Sequence and expression of the murine Hoxd-3 homeobox gene.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Hox genes in the lung.American journal of respiratory cell and molecular biology · 1996Review
- Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells.Molecular and cellular biology · 1996Article
- Transposon tools for recombinant DNA manipulation: characterization of transcriptional regulators from yeast, Xenopus, and mouse.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A long-range regulatory element of Hoxc8 identified by using the pClasper vector.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Independence and interdependence of the three human aldolase A promoters in transgenic mice.Gene expression · 1996Article
- The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.Molecular and cellular biology · 1995Article
- Improved in situ beta-galactosidase staining for histological analysis of transgenic mice.Histochemistry · 1994Article
- The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.The EMBO journal · 1994Article
- The molecular anatomy of Hox gene expression.Journal of anatomy · 1994Review
- Spatial localisation of transcripts of the Hox-C6 gene.Journal of anatomy · 1993Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In this study we have investigated the organization and regulation of the mouse Hox-2.7 gene. There are several alternative transcripts some of which are conserved between mouse and humans. By Northern and in situ analysis we are able to identify at least three types of transcripts which are different in size and splicing pattern and have distinctly different boundaries of expression in the nervous system. One subset of the endogenous transcripts has a boundary of expression that corresponds to the adjacent Hox-2.8 gene instead of Hox-2.7. In another type of transcript there is an alternative reading frame which predicts a protein that has homology to an enzyme ATPase and suggests that a non-homeobox containing gene may be located in the Hox-2 cluster. A Hox-2.7-lacZ transgene is expressed in a similar pattern to the endogenous gene in that spatially-restricted domains of expression are seen in the branchial arches, neural tube, paraxial mesoderm (somites), cranial ganglia, neural crest and gut. However, the anterior boundaries of transgene expression only correspond to the subset of Hox-2.7 transcripts which map to the Hox-2.8 boundary. The proximity of a Hox-2.7 promoter to regions which regulate the adjacent Hox-2.6 gene and the expression of transgenic and endogenous transcripts in a Hox-2.8 pattern, suggest that regulatory elements may be shared by neighbouring genes to establish the complete expression pattern.
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