Evidence map›Paper›PMID 15821401›Full record

ArticleAIDS (London, England)2005

Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations.

Elizabeth Johnston, Kathryn M Dupnik, Matthew J Gonzales, Mark A Winters, Soo-Yon Rhee, Tomozumi Imamichi, Robert W Shafer

Abstract read
In one paragraph

Article in AIDS (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  9. Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Rationale and uses of a public HIV drug-resistance database.The Journal of infectious diseases · 2006
    Review
  17. Article
  18. Drug resistance and antiretroviral drug development.The Journal of antimicrobial chemotherapy · 2005
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth JohnstonDivision of Infectious Diseases, Stanford University, Stanford, CA, USA.
Kathryn M Dupnik
Matthew J Gonzales
Mark A Winters
Soo-Yon Rhee
Tomozumi Imamichi
Robert W Shafer

Funding

Targeting ensembles of Drug Resistant HIV ProteasesP01GM066524 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANA, TARIQ M · 2002 to 2011
$16.3M
Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)R25TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, VERMUND, STEN H. · 2012 to 2016
$6.3M
IDENTIFICATION OF MULTIDRUG RESISTANT HIV1 ISOLATESR01AI046148 · NIAID · STANFORD UNIVERSITY · PI SHAFER, ROBERT WILLIAM · 1999 to 2008
$2.4M
FIC NIH HHS R25 TW009337NIAID NIH HHS AI-46148-03NIAID NIH HHS R01 AI046148NIGMS NIH HHS P01 GM066524
6 · The paper itself

Abstract

We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.

Indexed as

MutationClone CellsDrug Resistance, Multiple, ViralGenotypeHIV-1HIV InfectionsHIV Reverse TranscriptaseHumansReverse Transcriptase InhibitorsRNA, ViralVirus CultivationHIV Reverse TranscriptaseReverse Transcriptase InhibitorsRNA, Viral

Identifiers

PMID15821401
PMCPMC2573397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.