Evidence map›Paper›PMID 15821159›Full record

ReviewMolecular interventions2005

Twenty years of calcium imaging: cell physiology to dye for.

Harm J Knot, Ismail Laher, Eric A Sobie, Silvia Guatimosim, Leticia Gomez-Viquez, Hali Hartmann, Long-Sheng Song, W J Lederer, Wolfgang F Graier, Roland Malli and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Molecular interventions, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. CALIMA: The semi-automated open-source calcium imaging analyzer.Computer methods and programs in biomedicine · 2019
    Article
  8. α-synuclein interacts with PrPNature neuroscience · 2017
    Article
  9. Article
  10. Article
  11. Studying mitochondrial Ca(2+) uptake - a revisit.Molecular and cellular endocrinology · 2012
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Extracellular calcium as an integrator of tissue function.The international journal of biochemistry & cell biology · 2008
    Review
  17. Transcellular calcium transport in mammary epithelial cells.Journal of mammary gland biology and neoplasia · 2007
    Article
  18. Article
  19. Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents.American journal of physiology. Heart and circulatory physiology · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Harm J KnotDepartment of Pharmacology & Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL, USA.
Ismail Laher
Eric A Sobie
Silvia Guatimosim
Leticia Gomez-Viquez
Hali Hartmann
Long-Sheng Song
W J Lederer
Wolfgang F Graier
Roland Malli
Maud Frieden
Ole H Petersen
University of Florida · US

Funding

Austrian Science Fund FWF P 16860
6 · The paper itself

Abstract

The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.

Indexed as

AnimalsCalciumCalcium SignalingCell Physiological PhenomenaEndoplasmic ReticulumEndothelial CellsEpithelial CellsFluorescent DyesHumansModels, BiologicalMuscle, Smooth, VascularRatsSarcoplasmic ReticulumSignal TransductionTime FactorsCalciumFluorescent Dyes

Identifiers

PMID15821159
PMCPMC4861218
OpenAlexW2139250080

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.