ArticlePlant physiology2005
The pivotal roles of the plant S-adenosylmethionine decarboxylase 5' untranslated leader sequence in regulation of gene expression at the transcriptional and posttranscriptional levels.
Article in Plant physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Arginine, a key amino acid for nitrogen nutrition and metabolism of forest trees.Journal of experimental botany · 2025Review
- PagSAMDC4a-Mediated Polyamine Synthesis Regulate Vessel Differentiation Under Drought Stress Conditions in Poplar.Plant biotechnology journal · 2025Article
- HMolecular plant pathology · 2025Article
- JsSAMDC promotes polyamine synthesis and flowering genes to synergistically regulate female flower bud differentiation.Plant cell reports · 2025Article
- Natural variation in GNP3 determines grain number and grain yield in rice.Nature communications · 2025Article
- Plant Promoters and Terminators for High-Precision Bioengineering.Biodesign research · 2023Review
- One-Week Scutellar Somatic Embryogenesis in the MonocotPlants (Basel, Switzerland) · 2022Article
- Genome-wide identification and characterization of the GDP-L-galactose phosphorylase gene family in bread wheat.BMC plant biology · 2019Article
- Identification of differentially expressed transcripts at critical developmental stages in sorghum [3 Biotech · 2019Article
- Increasing Polyamine Contents Enhances the Stress ToleranceFrontiers in plant science · 2019Article
- Polyamines in the life of Arabidopsis: profiling the expression of S-adenosylmethionine decarboxylase (SAMDC) gene family during its life cycle.BMC plant biology · 2017Article
- Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics.BMC genomics · 2017Article
- Molecular cloning and characterization ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2017Article
- Transcriptomic Analysis of Soil GrownFrontiers in plant science · 2017Article
- Characterization of 5'UTR of rice ClpB-C/Hsp100 gene: evidence of its involvement in post-transcriptional regulation.Cell stress & chaperones · 2016Article
- Down-Regulating CsHT1, a Cucumber Pollen-Specific Hexose Transporter, Inhibits Pollen Germination, Tube Growth, and Seed Development.Plant physiology · 2015Article
- The transcription factor AREB1 regulates primary metabolic pathways in tomato fruits.Journal of experimental botany · 2014Article
- Deciphering the role of various cis-acting regulatory elements in controlling SamDC gene expression in rice.Plant signaling & behavior · 2014Article
- Polyamines and abiotic stress in plants: a complex relationship.Frontiers in plant science · 2014Review
- Stress and polyamine metabolism in fungi.Frontiers in chemistry · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S-Adenosylmethionine decarboxylase (SAMDC; EC 4.1.1.50) is a key rate-limiting enzyme located in the polyamine biosynthesis pathway. When compared with other organisms, the plant SAMDC genes possess some distinct features because they are devoid of introns in the main open reading frame (ORF) but have an intron(s) in their 5' untranslated leader sequences, in which two overlapping tiny and small upstream ORFs (uORFs) are present. Our results show that the presence of the 5' leader sequence plays important roles in transcriptional and posttranscriptional regulation of SAMDC expression. This sequence may help to keep the transcript of its downstream cistron at a relatively low level and function together with its own promoter in response to external stimuli or internal changes of spermidine and spermine to initiate and regulate SAMDC expression. Under stress and high spermidine or spermine conditions, the tiny uORF shows the same function as its overlapping small uORF, which is involved in translational repression and feedback controlled by polyamines. The presence of introns is necessary for the SAMDC up-regulation process when the internal spermidine level is low. Our results suggest that plants have evolved one network to adjust SAMDC activity through their 5' leader sequences, through which transcriptional regulation is combined with an extensive posttranscriptional control circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.