ArticleEukaryotic cell2005
Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Architecture of the dynamic fungal cell wall.Nature reviews. Microbiology · 2023Review
- Prevalence, Molecular Identification, and Genotyping ofAdvanced biomedical research · 2022Article
- Yeast Cells in Microencapsulation. General Features and Controlling Factors of the Encapsulation Process.Molecules (Basel, Switzerland) · 2021Review
- Engineering of Yeast Glycoprotein Expression.Advances in biochemical engineering/biotechnology · 2021Article
- Article
- The MNN2 Gene Knockout Modulates the Antifungal Resistance of Biofilms of Candida glabrata.Biomolecules · 2018Article
- Article
- The APSES transcription factor Vst1 is a key regulator of development in microsclerotium- and resting mycelium-producing Verticillium species.Molecular plant pathology · 2018Article
- N-glycan mediated adhesion strengthening during pathogen-receptor binding revealed by cell-cell force spectroscopy.Scientific reports · 2017Article
- Phosphomannosylation and the Functional Analysis of the ExtendedFrontiers in microbiology · 2017Article
- Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.PloS one · 2017Article
- The F-box protein Fbp1 functions in the invasive growth and cell wall integrity mitogen-activated protein kinase (MAPK) pathways in Fusarium oxysporum.Molecular plant pathology · 2016Article
- Mannosylation in Candida albicans: role in cell wall function and immune recognition.Molecular microbiology · 2013Review
- Insight into the antiadhesive effect of yeast wall protein 1 of Candida albicans.Eukaryotic cell · 2012Article
- A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions.The Journal of biological chemistry · 2010Article
- A Candida albicans early stage biofilm detachment event in rich medium.BMC microbiology · 2009Article
- Dendritic cell interaction with Candida albicans critically depends on N-linked mannan.The Journal of biological chemistry · 2008Article
- Eap1p, an adhesin that mediates Candida albicans biofilm formation in vitro and in vivo.Eukaryotic cell · 2007Article
- Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.The Journal of clinical investigation · 2006Article
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Authors and funding
3 authors.
Funding
Abstract
Cell surface hydrophobicity (CSH) of Candida species enhances virulence by promoting adhesion to host tissues. Biochemical analysis of yeast cell walls has demonstrated that the most significant differences between hydrophobic and hydrophilic yeasts are found in the acid-labile fraction of Candida albicans phosphomannoprotein, suggesting that this fraction is important in the regulation of the CSH phenotype. The acid-labile fraction of C. albicans is unique among fungi, in that it is composed of an extended polymer of beta-1,2-mannose linked to the acid-stable region of the N-glycan by a phosphodiester bond. C. albicans serotype A and B strains both contain a beta-1,2-mannose acid-labile moiety, but only serotype A strains contain additional beta-1,2-mannose in the acid-stable region. A knockout of the C. albicans homolog of the Saccharomyces cerevisiae MNN4 gene was generated in two serotype B C. albicans patient isolates by using homologous gene replacement techniques, with the anticipation that they would be deficient in the acid-labile fraction and, therefore, demonstrate perturbed CSH. The resulting mnn4delta-deficient derivative has no detectable phosphate-linked beta-1,2-mannose in its cell wall, and hydrophobicity is increased significantly under conditions that promote the hydrophilic phenotype. The mnn4delta mutant also demonstrates an unanticipated perturbation in the acid-stable mannan fraction. The present study reports the first genetic knockout constructed in a serotype B C. albicans strain and represents an important step for dissecting the regulation of CSH.
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