ReviewDrugs2005
Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs.
Review in Drugs, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01238705 (Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Combined Antihypertensive Therapy on Blood Pressure and Sexual Function in Patients With Essential Hypertension
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Effects of Major Antihypertensive Drug Classes on Erectile Function: a Network Meta-analysis.Cardiovascular drugs and therapy · 2022Pooled it
- Quality of Life, Sexual Functioning and Chronic Disease: A Comparative Study with Portuguese Women without Chronic Disease, and Women with Diabetes Type 1 and 2, and Arterial Hypertension.International journal of sexual health : official journal of the World Association for Sexual Health · 2022Article
- Sexual Health in the Elderly Population.Current sexual health reports · 2020Article
- Toward implementation of sexual healthcare, Response to: 'The opinion and practices of providers toward the sexual issues of cervical cancer patients undergoing treatment'.Gynecologic oncology reports · 2017Article
- [Influence of drugs on urological diseases].Der Urologe. Ausg. A · 2016Review
- Tolerability of Antihypertensive Medications in Older Adults.Drugs & aging · 2015Review
- Abnormalities of Reproductive Function in Male Obesity Before and After Bariatric Surgery-A Comprehensive Review.Obesity surgery · 2015Review
- Article
- Sexual activity and ischemic heart disease.Current cardiology reports · 2014Review
- How to treat erectile dysfunction in men with diabetes: from pathophysiology to treatment.Current diabetes reports · 2014Review
- A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2014Article
- What do cardiologists know about the effects of cardiovascular agents on sexual function? A survey among Dutch cardiologists. Part I.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2013Article
- Erectile dysfunction and hypertension: impact on cardiovascular risk and treatment.International journal of hypertension · 2012Article
- [Diuretics in the treatment of hypertension. Efficacy, safety and tolerability].Der Internist · 2011Article
- Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers.Drug, healthcare and patient safety · 2010Article
- RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection.Clinical research in cardiology : official journal of the German Cardiac Society · 2008Review
- Drug-induced endocrine and metabolic disorders.Drug safety · 2007Review
- Review
- Review
- Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem.International journal of impotence research · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has been proposed that sexual and especially erectile dysfunction may, at least in part, represent just another manifestation of atherosclerotic vascular disease. In addition to hypertension itself, sexual function in male hypertensive patients may also be affected by antihypertensive drug treatment. Available evidence suggests that centrally acting sympatholytic agents, beta-adrenoceptor antagonists (beta-blockers) and diuretics may have the potential to further impair sexual function. Calcium channel antagonists and ACE inhibitors may be neutral with respect to this endpoint. Preliminary data from several randomised and open studies have suggested that angiotensin II (AT)(1)-receptor antagonists may even be associated with an improvement of sexual function. However, many aspects of the interaction between hypertension, antihypertensive drug treatment and male sexual function remain unclear. Among other factors, the relative contribution of disease labelling both to the higher incidence of sexual dysfunction in hypertensive versus normotensive males and to the negative impact of treatment remains an open question. Furthermore, dose dependence of the observed effects of antihypertensive agents on sexual function, the role of combination therapy and the anticipation of proposed adverse effects of treatment are unresolved issues. Thus, more data from studies of high quality using standardised definitions and procedures are urgently needed to at least partially resolve some of the many open questions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.