ArticleWorld journal of gastroenterology2005
Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Rhein alleviates acute pancreatitis by inhibiting TMAO-mediated inflammatory signaling pathways and reducing acinar cell injury.Journal of advanced research · 2026Article
- Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review).Experimental and therapeutic medicine · 2022Review
- Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury - A Narrative Review.Journal of inflammation research · 2021Review
- Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial.The Libyan journal of medicine · 2019Article
- Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation.Toxicology and applied pharmacology · 2016Article
- Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas.Oncotarget · 2016Article
- Effect of tiron on remote organ injury in rats with severe acute pancreatitis induced by L-arginine.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Ischemia-reperfusion rat model of acute pancreatitis: protein carbonyl as a putative early biomarker of pancreatic injury.Clinical and experimental medicine · 2015Article
- Obestatin Accelerates the Recovery in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats.PloS one · 2015Article
- Biliopancreatic duct injection of ethanol as an experimental model of acute and chronic pancreatitis in rats.International journal of clinical and experimental medicine · 2015Article
- Research on scutellarin parenteral solution's protective effects in rats with severe acute pancreatitis and multiple organ injuries.Inflammation · 2012Article
- Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.PloS one · 2012Article
- Ascitic fluid and serum from rats with acute pancreatitis injure rat pancreatic tissues and alter the expression of heat shock protein 60.Cell stress & chaperones · 2010Article
- Antioxidants in acute pancreatitis.Gut · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP). Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.
methodsAP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.
resultsHistopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.
conclusionNO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress.
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