ArticleLeukemia2005
Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances.
Article in Leukemia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 86 citations in OpenAlex.
- Long-term survival outcomes of reduced-intensity allogeneic or autologous transplantation in relapsed grade 3 follicular lymphoma.Bone marrow transplantation · 2016Trial
- New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications.International journal of hematology · 2025Review
- The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.Blood advances · 2023Article
- Follicular lymphoma: updates for pathologists.Journal of pathology and translational medicine · 2022Review
- Upward trend in follicular lymphoma among the Korean population: 10-year experience at a large tertiary institution.Journal of pathology and translational medicine · 2021Article
- Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia.Frontiers of medicine · 2021Review
- Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tract.Scientific reports · 2021Article
- High-grade B-cell Lymphoma withDiagnostics (Basel, Switzerland) · 2020Article
- Article
- Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma.Frontiers in medicine · 2019Review
- Epidemiology and secular trends of malignant lymphoma in Japan: Analysis of 9426 cases according to the World Health Organization classification.Cancer medicine · 2018Article
- CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine.Cancer science · 2016Article
- Follicular lymphoma grade 3B: is it a real disease?Haematologica · 2011Article
- Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.Leukemia research · 2010Article
- Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era.Cancer science · 2009Article
- Follicular lymphoma of the thyroid gland.The American journal of surgical pathology · 2009Article
- Prognostic significance of B-cell differentiation genes encoding proteins in diffuse large B-cell lymphoma and follicular lymphoma grade 3.Croatian medical journal · 2008Article
- Analysis of follicular lymphoma by dual-color fluorescence in situ hybridization.Virchows Archiv : an international journal of pathology · 2008Article
- Article
- ''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases.The Journal of molecular diagnostics : JMD · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Follicular lymphomas (FL) are morphologically classified into grades 1, 2, 3a and 3b by the World Health Organization. Bcl2, Bcl6 and CD10 are phenotypic markers of FL while the Bcl2 t(14;18) and Bcl6 t(3q27) gene translocations are common genetic changes. However, to date, there has been no integrated analysis based on phenotype, grade and genotype from large numbers of FL cases. We graded 261 cases of FL and determined their phenotypes and gene alterations. According to the antigen markers and gene alterations of 147 cases, we classified FL into typical and the others types. The typical group, which includes 69% cases of FL, is characterized by low histological grade (grade 1, 2), coexpression of BCL2 and CD10 and Bcl2 gene translocation. The rest comprises a small part of low-grade FL without Bcl2 gene translocation and high-grade (grade 3a, 3b) FL. These FLs include some heterogeneous disease entities. They are characterized by high histological grade (87%), no definite expression of BCL2 or CD10 and several kinds of gene aberrances including Bcl2 translocation, Bcl6 translocation, Bcl2 amplification or other unknown gene abnormality. Our findings indicate that typical FL presents a homogeneous disease entity whereas the rest comprises heterogeneous diseases entities.
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