ArticleJournal of clinical microbiology2005
Internally controlled real-time PCR monitoring of adenovirus DNA load in serum or plasma of transplant recipients.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 128 citations in OpenAlex.
- Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection.Haematologica · 2010Trial
- Development of a Rapid Isothermal Assay for Detection of Adenovirus Types Important in Respiratory Infections.Influenza and other respiratory viruses · 2025Article
- Clinical manifestations, prognostic factors, and outcomes of adenovirus pneumonia after allogeneic hematopoietic stem cell transplantation.Virology journal · 2024Article
- Allograft adenovirus nephritis accompanied by Crohn's disease in a kidney transplant recipient: a novel case report.CEN case reports · 2023Article
- Safety and efficacy of brincidofovir for Adenovirus infection in children receiving allogeneic stem cell transplantation: an AIEOP retrospective analyses.Bone marrow transplantation · 2021Article
- Comparison of Three Adenovirus Quantitative PCR Assays with ATCC Reference Strains and Clinical Samples.Journal of clinical microbiology · 2019Article
- Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort.BMJ (Clinical research ed.) · 2019Article
- Differential Elimination of Anti-Thymocyte Globulin of Fresenius and Genzyme Impacts T-Cell Reconstitution After Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2019Article
- Disseminated adenovirus infection in a 10-year-old renal allograft recipient.Kidney research and clinical practice · 2018Article
- A study of polymerase chain reaction device control via cloud using Firebase Cloud Messaging protocol.Biomedical engineering online · 2018Article
- The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly.Biomedicines · 2018Review
- Viral gastroenteritis in children in Colorado 2006-2009.Journal of medical virology · 2015Article
- Outcomes of early administration of cidofovir in non-immunocompromised patients with severe adenovirus pneumonia.PloS one · 2015Article
- Prevalence of adenovirus respiratory tract and hiv co-infections in patients attending the University of Ilorin, teaching hospital, Ilorin, Nigeria.BMC research notes · 2014Article
- Adenovirus infections in immunocompetent and immunocompromised patients.Clinical microbiology reviews · 2014Review
- Other viral pneumonias: coronavirus, respiratory syncytial virus, adenovirus, hantavirus.Critical care clinics · 2013Review
- Improved real-time PCR assay for detection and quantification of all 54 known types of human adenoviruses in clinical samples.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Real-time qualitative PCR for 57 human adenovirus types from multiple specimen sources.Journal of clinical microbiology · 2012Article
- Application of molecular diagnostic techniques for viral testing.The open virology journal · 2012Article
- Comparison of in-house real-time quantitative PCR to the Adenovirus R-Gene kit for determination of adenovirus load in clinical samples.Journal of clinical microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenoviruses have been recognized as important pathogens in immunocompromised hosts. Particularly in pediatric allogeneic stem cell transplant recipients, the morbidity of the patients and mortality in those patients with disseminated infections have been found to increase over the last few years. Severe infections are predominantly but not exclusively caused by subgroup C adenoviruses. A multiplex real-time PCR assay using molecular beacons as probes was developed to enable monitoring of adenovirus DNA in those patients with simultaneous identification of subgroups. An internal control was coamplified in the multiplex PCR to check for the DNA isolation procedure as well as the presence of inhibitors in the clinical samples. The assay has been applied retrospectively in patient groups with different clinical outcomes of infection. In fatal cases, significantly higher adenovirus loads developed, exceeding even 10(11) copies/ml of serum or plasma. Patients with viral loads over 10(6) copies/ml appear to have an increased risk for fatal complications. This quantitative real-time PCR assay has been prospectively used clinically since 2002 to study the course of adenovirus infection. In addition, the assay provides objective start and end points of therapeutic interventions, including the clinically important evaluation of antiviral drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.