ArticleJournal of clinical microbiology2005
Comparing genomes of Helicobacter pylori strains from the high-altitude desert of Ladakh, India.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics.Microorganisms · 2025Article
- Expression analysis of miRNA-155 level inIranian journal of microbiology · 2022Article
- A report of nonexistence of the non-Helicobacter pylori Helicobacter species in Iranian patients suffering from inflammatory bowel disease.Folia microbiologica · 2021Article
- Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China.Gut pathogens · 2021Article
- Prevalence of tumor necrosis factor alpha inducing protein (3 Biotech · 2021Article
- Oral rinses in growth inhibition and treatment of Helicobacter pylori infection.BMC microbiology · 2020Article
- The analysis of virulence factors and antibiotic resistance between Helicobacter pylori strains isolated from gastric antrum and body.BMC gastroenterology · 2019Article
- Helicobacter pylori isolated from Iranian drinking water: vacA, cagA, iceA, oipA and babA2 genotype status and antimicrobial resistance properties.FEBS open bio · 2016Article
- Helicobacter pylori in bottled mineral water: genotyping and antimicrobial resistance properties.BMC microbiology · 2016Article
- VacA, cagA, iceA and oipA genotypes status and antimicrobial resistance properties of Helicobacter pylori isolated from various types of ready to eat foods.Annals of clinical microbiology and antimicrobials · 2016Article
- No Association between CagA- and VacA-Positive Strains of Helicobacter pylori and Primary Open-Angle Glaucoma: A Case-Control Study.Ophthalmology and eye diseases · 2016Article
- Helicobacter pylori with the Intact dupA Cluster is more Virulent than the Strains with the Incomplete dupA Cluster.Current microbiology · 2015Article
- Infection with CagA-positive Helicobacter pylori strain containing three EPIYA C phosphorylation sites is associated with more severe gastric lesions in experimentally infected Mongolian gerbils (Meriones unguiculatus).European journal of histochemistry : EJH · 2015Article
- Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran.World journal of microbiology & biotechnology · 2014Article
- Helicobacter pylori in vegetables and salads: genotyping and antimicrobial resistance properties.BioMed research international · 2014Article
- Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders.World journal of gastroenterology · 2013Article
- Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.Polish journal of microbiology · 2010Article
- Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer.Journal of clinical microbiology · 2009Article
- vacA genotypes of Helicobacter pylori in relation to cagA status and clinical outcomes in Iranian populations.Japanese journal of infectious diseases · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genomic diversity of Helicobacter pylori from the vast Indian subcontinent is largely unknown. We compared the genomes of 10 H. pylori strains from Ladakh, North India. Molecular analysis was carried out to identify rearrangements within and outside the cag pathogenicity island (cag PAI) and DNA sequence divergence in candidate genes. Analyses of virulence genes (such as the cag PAI as a whole, cagA, vacA, iceA, oipA, babB, and the plasticity cluster) revealed that H. pylori strains from Ladakh are genetically distinct and possibly less virulent than the isolates from East Asian countries, such as China and Japan. Phylogenetic analyses based on the cagA-glr motifs, enterobacterial repetitive intergenic consensus patterns, repetitive extragenic palindromic signatures, the glmM gene mutations, and several genomic markers representing fluorescent amplified fragment length polymorphisms revealed that Ladakhi strains share features of the Indo-European, as well as the East Asian, gene pools. However, the contribution of genetic features from the Indo-European gene pool was more prominent.
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