ArticleNucleic acids research2005
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Development of Force Field Parameters for the Simulation of Single- and Double-Stranded DNA Molecules and DNA-Protein Complexes.The journal of physical chemistry. B · 2022Article
- Article
- Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Nucleic acids research · 2016Article
- The intrinsic mechanics of B-DNA in solution characterized by NMR.Nucleic acids research · 2016Article
- A targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity.FEBS open bio · 2016Article
- Unprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravir.PloS one · 2012Article
- Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis.PloS one · 2011Article
- HIV-1 integrase and virus and cell DNAs: complex formation and perturbation by inhibitors of integration.Neurochemical research · 2010Article
- HIV-1 Integrase-DNA Recognition Mechanisms.Viruses · 2009Article
- Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.Nucleic acids research · 2009Article
- Structural and dynamic characterization of the upper part of the HIV-1 cTAR DNA hairpin.Nucleic acids research · 2009Article
- General method of preparation of uniformly 13C, 15N-labeled DNA fragments for NMR analysis of DNA structures.Journal of biomolecular NMR · 2006Article
- Sequence-dependent gating of an ion channel by DNA hairpin molecules.Nucleic acids research · 2006Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of the human immunodeficiency virus type 1 DNA into the host cell genome is catalysed by the viral integrase (IN). The reaction consists of a 3'-processing [dinucleotide released from each 3' end of the viral long terminal repeat (LTR)] followed by a strand transfer (insertion of the viral genome into the human chromosome). A 17 base pair oligonucleotide d(GGAAAATCTCTAGCAGT), d(ACTGCTAGAGATTTTCC) reproducing the U5-LTR extremity of viral DNA that contains the IN attachment site was analysed by NMR using the classical NOEs and scalar coupling constants in conjunction with a small set of residual dipolar coupling constants (RDCs) measured at the 13C/15N natural abundance. The combination of these two types of parameters in calculations significantly improved the DNA structure determination. The well-known features of A-tracts were clearly identified by RDCs in the first part of the molecule. The binding/cleavage site at the viral DNA end is distinguishable by a loss of regular base stacking and a distorted minor groove that can aid its specific recognition by IN.
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