ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125 citing papers in PubMed, 210 citations in OpenAlex.
- A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.Cell chemical biology · 2026Article
- Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents.Journal of neurophysiology · 2026Article
- Neuronal excitability and parameter variability in the Hodgkin-Huxley model.PLoS computational biology · 2026Article
- Homeostatic preservation of action potential waveform by Notch and Nerfin-1.Current biology : CB · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition.bioRxiv : the preprint server for biology · 2025Article
- Higher-order interactions in neuronal function: From genes to ionic currents in biophysical models.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Dimensionality reduction of neuronal degeneracy reveals two interfering physiological mechanisms.PNAS nexus · 2024Article
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- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- A biophysical perspective on the resilience of neuronal excitability across timescales.Nature reviews. Neuroscience · 2023Review
- Ion-channel degeneracy and heterogeneities in the emergence of complex spike bursts in CA3 pyramidal neurons.The Journal of physiology · 2023Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Homeostatic regulation of neuronal function: importance of degeneracy and pleiotropy.Frontiers in cellular neuroscience · 2023Review
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65 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
Cerebellar Purkinje neurons often generate all-or-none burst firing in response to depolarizing stimuli. Voltage-clamp experiments using action potential waveforms show that burst firing depends on small net inward currents that flow after spikes and reflect the net balance between multiple large currents. Given this, burst firing is surprisingly robust in the face of changes in the magnitude of the underlying currents from cell to cell. We explored the basis of this robustness by examining the effects of reducing the sodium current, the major contributor to the postspike inward current. Burst firing persisted in concentrations of tetrodotoxin that produced half-block of sodium current. This robustness of bursting reflects an acute feedback mechanism whereby waveform changes from the reduced sodium current (reduced spike height and a hyperpolarizing shift in postspike voltage) cause compensatory decreases in postspike potassium currents. In particular, reduced spike height reduces calcium entry and subsequent calcium-activated potassium current, and the hyperpolarizing shift in postspike voltage speeds deactivation of Kv3-like potassium channels. Other experiments examined bursting in Na(v)1.6-/- mice, in which sodium current density is reduced in the long term. Under these circumstances, there was upregulation of both T-type and P-type calcium current and a change in the balance of calcium current and calcium-activated potassium current such that their net influence shifted from being inhibitory during bursts in wild-type neurons to excitatory during bursts from Na(v)1.6-/- mutant neurons. Thus, Purkinje neurons have both acute and long-term feedback mechanisms that serve to maintain burst firing when voltage-dependent sodium conductance is reduced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.