ReviewInternational journal of hematology2005
In vivo platelet production from mature megakaryocytes: does platelet release occur via proplatelets?
Review in International journal of hematology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Looking Under the Hood at the Cytoskeletal Engine of Platelet Production.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Relationship between haemodynamic indicators and haemogram in patients with heart failure.ESC heart failure · 2023Article
- The Analysis of the Human Megakaryocyte and Platelet Coding Transcriptome in Healthy and Diseased Subjects.International journal of molecular sciences · 2022Review
- The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis.Cell death & disease · 2021Article
- New insights into cytoskeletal remodeling during platelet production.Journal of thrombosis and haemostasis : JTH · 2019Review
- Megakaryocytes as immune cells.Journal of leukocyte biology · 2019Review
- Misunderstandings Between Platelets and Neutrophils Build in Chronic Inflammation.Frontiers in immunology · 2019Review
- Imaging platelet biogenesis in vivo.Research and practice in thrombosis and haemostasis · 2018Review
- Induction of Apoptosis in Cancer Cells of pre-B ALL Patients after Exposure to Platelets, Platelet-Derived Microparticles and Soluble CD40 Ligand.Cell journal · 2018Article
- Stem cell autotomy and niche interaction in different systems.World journal of stem cells · 2015Review
- The role of platelets in the pathogenesis of systemic sclerosis.Frontiers in immunology · 2012Article
- Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.Cell research · 2011Article
- Thrombocytogenesis by megakaryocyte; Interpretation by protoplatelet hypothesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2011Review
- Platelets as delivery systems for disease treatments.Advanced drug delivery reviews · 2010Review
- In vitro megakaryocyte production and platelet biogenesis: state of the art.Transfusion medicine reviews · 2010Review
- Platelet production by megakaryocytes: protoplatelet theory justifies cytoplasmic fragmentation model.International journal of hematology · 2008Review
- Mechanisms of organelle transport and capture along proplatelets during platelet production.Blood · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although platelets are universally accepted to be born from megakaryocytes (MKs), the mechanism by which platelets are formed and released from MKs in vivo remains controversial. One theory, known as the proplatelet theory, postulates that platelets are released from proplatelet processes protruding from MKs into sinusoids located in the bone marrow hematopoietic compartment. Proplatelet formation (PPF) has been observed in in vitro experiments involving detailed analyses of related molecular events. PPF has also been used as a marker of MK maturation. However, PPF is suggested to be a nonphysiological phenomenon. On the other hand, transmission electron microscopy (TEM) analyses have revealed platelet formation via explosive fragmentation of MK cytoplasm in bone marrow and lung capillaries prepared by immersion fixation. Moreover, TEM and scanning electron microscopy studies of liquid-cultured MKs kept in suspension show that platelet formation occurs without PPF. Rather, an explosive and global fragmentation of the MK cytoplasm composed of platelet territories has been reported as the mechanism of platelet formation. In addition, in vivo and ex vivo observations of platelet release from MKs with phase-contrast microscopy strongly support the explosive-fragmentation theory. With all observations taken into account, PPF may not be a prerequisite for platelet release from MKs under real-life conditions. In this review, a new "protoplatelet" concept is proposed to support the explosive-fragmentation theory. Additionally, the role of the lungs in platelet production is reviewed and discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.