ArticleBiomaterials2005
Nanopattern-induced changes in morphology and motility of smooth muscle cells.
Article in Biomaterials, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 624 citations in OpenAlex.
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- Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus.Journal of advanced research · 2025Review
- Advanced Strategies for Enhancing the Biocompatibility and Antibacterial Properties of Implantable Structures.Materials (Basel, Switzerland) · 2025Review
- Neural growth patterns: how random and aligned fibers guide 3D cell organization and pseudospheroid formation.Frontiers in bioengineering and biotechnology · 2025Article
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- Hs27 fibroblast response to contact guidance cues.Scientific reports · 2023Article
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- Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors.Journal of nanobiotechnology · 2023Review
- Esophageal wound healing by aligned smooth muscle cell-laden nanofibrous patch.Materials today. Bio · 2023Article
- Fucoidan and topography modification improvedBioactive materials · 2023Article
- Surface Engineering of a Bioartificial Membrane for Its Application in Bioengineering Devices.ACS omega · 2023Review
- The influence of nanotopography on cell behaviour through interactions with the extracellular matrix - A review.Bioactive materials · 2022Review
- Bioactivation of 3D Cell-Imprinted Polydimethylsiloxane Surfaces by Bone Protein Nanocoating for Bone Tissue Engineering.ACS omega · 2022Article
- Microbial Response to Micrometer-Scale Multiaxial Wrinkled Surfaces.ACS applied materials & interfaces · 2022Article
- Mammalian Cell Interaction with Periodic Surface Nanostructures.International journal of molecular sciences · 2022Article
- Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells.Applied sciences (Basel, Switzerland) · 2022Article
- Recent advances in engineering nanotopographic substrates for cell studies.Frontiers in bioengineering and biotechnology · 2022Review
- Nanomaterial-Based Immunocapture Platforms for the Recognition, Isolation, and Detection of Circulating Tumor Cells.Frontiers in bioengineering and biotechnology · 2022Review
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cells are known to be surrounded by nanoscale topography in their natural extracellular environment. The cell behavior, including morphology, proliferation, and motility of bovine pulmonary artery smooth muscle cells (SMC) were studied on poly(methyl methacrylate) (PMMA) and poly(dimethylsiloxane) (PDMS) surfaces comprising nanopatterned gratings with 350 nm linewidth, 700 nm pitch, and 350 nm depth. More than 90% of the cells aligned to the gratings, and were significantly elongated compared to the SMC cultured on non-patterned surfaces. The nuclei were also elongated and aligned. Proliferation of the cells was significantly reduced on the nanopatterned surfaces. The polarization of microtubule organizing centers (MTOC), which are associated with cell migration, of SMC cultured on nanopatterned surfaces showed a preference towards the axis of cell alignment in an in vitro wound healing assay. In contrast, the MTOC of SMC on non-patterned surfaces preferentially polarized towards the wound edge. It is proposed that this nanoimprinting technology will provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.