ArticleJournal of inflammation (London, England)2004
Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression
Article in Journal of inflammation (London, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Lipid-based vectors for siRNA delivery.Journal of drug targeting · 2012Review
- Nanomedicine in GI.American journal of physiology. Gastrointestinal and liver physiology · 2011Review
- Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin.BMC dermatology · 2011Article
- Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.Nature reviews. Drug discovery · 2010Review
- Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA.Nature materials · 2009Article
- Can CYP1A1 siRNA be an effective treatment for lung cancer?Cellular & molecular biology letters · 2008Article
- Inhibition of white spot syndrome virus inAquaculture (Amsterdam, Netherlands) · 2007Article
- Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo.Applied microbiology and biotechnology · 2007Review
- Progress towards in vivo use of siRNAs.Molecular therapy : the journal of the American Society of Gene Therapy · 2006Review
- A novel method of modifying immune responses by vaccination with lipiodol-siRNA mixtures.Journal of translational medicine · 2006Article
- Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo.Journal of biomedicine & biotechnology · 2006Article
- Mesenchymal stem cells avoid allogeneic rejection.Journal of inflammation (London, England) · 2005Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRNA interference is an evolutionary conserved immune response mechanism that can be used as a tool to provide novel insights into gene function and structure. The ability to efficiently deliver small interfering RNA to modulate gene expression
methods
resultsIn this report, we show that IL-12p40 siRNA can specifically silence macrophage expression of IL-12p40 mRNA and IL-12p70 protein
conclusion
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.