ReviewDrugs & aging2005
Merkel cell carcinoma of skin: diagnosis and management strategies.
Review in Drugs & aging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The impact of merkel cell polyomavirus positivity on prognosis of merkel cell carcinoma: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma.Future oncology (London, England) · 2017Pooled it
- Merkel cell carcinoma: Clinicopathological analysis of three patients and literature review.Open life sciences · 2025Article
- Merkel Cell Carcinoma of the Head and Neck: Epidemiology, Pathogenesis, Current State of Treatment and Future Directions.Cancers · 2021Review
- Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma.Cancers · 2020Article
- Merkel Cell Carcinoma: Therapeutic Update and Emerging Therapies.Dermatology and therapy · 2019Review
- Merkel cell carcinoma of the head and neck: emphasizing the risk of undertreatment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Observational
- The effect of resveratrol in combination with irradiation and chemotherapy: study using Merkel cell carcinoma cell lines.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Merkel cell carcinoma: a review and update on aetiopathogenesis, diagnosis and treatment approaches.Wiener medizinische Wochenschrift (1946) · 2013Review
- Merkel cell carcinoma.American journal of clinical oncology · 2013Review
- Activation of PI3K signaling in Merkel cell carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status.Journal of skin cancer · 2012Article
- A Review of Carcinomas Arising in the Head and Neck Region in HIV-Positive Patients.Pathology research international · 2011Article
- Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.Virchows Archiv : an international journal of pathology · 2009Article
- Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma.British journal of cancer · 2009Article
- Epidermoid cyst mimicry: report of seven cases and review of the literature.The Journal of clinical and aesthetic dermatology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Merkel cell carcinoma (MCC) of the skin is a rare form of cutaneous malignancy of neuroendocrine origin with a propensity to affect predominately elderly patients in sun-exposed areas. The tumour has an extremely aggressive growth pattern with the potential to seed into the dermal lymphatics at an early stage as well as spread to nodes and distant sites. Successful outcomes can be achieved with early diagnosis and a multidisciplinary approach to management. Patients with MCC should be carefully staged to exclude distant metastatic disease. Treatment should be approached with both the primary site and the lymph nodes in mind. The primary site should be excised with clear margins, followed by postoperative radiotherapy to the primary site and affected nodes. Addition of chemotherapy to patients perceived to be at high-risk of distant recurrence (e.g. those with involved nodes) has been considered, but evidence supporting this approach is relatively scant. This treatment strategy needs to be approached with caution in the elderly because of the risk of myelosuppression. An aggressive treatment approach is warranted at the first attempt to treat MCC as treatment for recurrent disease is less likely to be successful.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.