ReviewEuropean archives of psychiatry and clinical neuroscience2005
Antidepressive effects of traditional and second generation antipsychotics: a review of the clinical data.
Review in European archives of psychiatry and clinical neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Effect of 5-HTNeuropsychiatric disease and treatment · 2021Article
- ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Risperidone, quetiapine, and olanzapine adjunctive treatments in major depression with psychotic features: a comparative study.Neuropsychiatric disease and treatment · 2013Article
- Can we really prevent suicide?Current psychiatry reports · 2012Review
- Forms of antipsychotic therapy: improved individual outcomes under personalised treatment of schizophrenia focused on depression.The EPMA journal · 2011Article
- Utility of atypical antipsychotics in the treatment of resistant unipolar depression.CNS drugs · 2009Review
- Antipsychotics possessing antidepressive efficacy increase Golf protein in rat striatum.Psychopharmacology · 2008Article
- Systematic of psychiatric disorders between categorical and dimensional approaches: Kraepelin's dichotomy and beyond.European archives of psychiatry and clinical neuroscience · 2008Review
- An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.European journal of pharmacology · 2008Article
- Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual review.European archives of psychiatry and clinical neuroscience · 2006Review
- Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms?European archives of psychiatry and clinical neuroscience · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For a long time,in the context of depressive symptoms in schizophrenia traditional neuroleptics were mostly discussed with respect to possible depressiogenic side effects, although some studies argued that they may also have certain antidepressive effects. However, this was not proven at that time in placebo-controlled studies. Placebo-controlled studies performed in recent years have shown that second generation antipsychotics have antidepressive effects which are significantly stronger than those of the traditional neuroleptics. In addition, it was demonstrated that this antidepressive effect can only partially be explained as being secondary to the improvement of positive and negative symptoms, and is apparently predominantly due to a direct (primary) effect on depressive symptoms. It is of special relevance in this context that the antidepressive effect of second generation antipsychotics was recently demonstrated in depression. The positive results from some studies in bipolar depression are especially impressive and underline the antidepressive potencies of novel antipsychotics beyond the spectrum of schizophrenia.
Indexed as
Identifiers
15812601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.