ArticleBritish journal of cancer2005
Absence of a specific radiation signature in post-Chernobyl thyroid cancers.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pooled it
- Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident.PloS one · 2012Trial
- Post-Chornobyl thyroid papillary carcinomas display distinct pastScientific reports · 2026Article
- Differential Expression of ATM, NF-KB, PINK1 and Foxo3a in Radiation-Induced Basal Cell Carcinoma.International journal of molecular sciences · 2023Article
- Article
- The role of mitochondrial oxidative stress and the tumor microenvironment in radiation-related cancer.Journal of radiation research · 2021Review
- The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study.Cancer biology & therapy · 2020Article
- Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.Radiation oncology (London, England) · 2020Article
- Molecular testing in the diagnosis of differentiated thyroid carcinomas.Gland surgery · 2018Review
- Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.Cancers · 2017Review
- Gene signature of the post-Chernobyl papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2016Article
- Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.Journal of radiation research · 2016Article
- Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas.Carcinogenesis · 2015Article
- Radiation signatures in childhood thyroid cancers after the Chernobyl accident: possible roles of radiation in carcinogenesis.Cancer science · 2015Review
- Molecular diagnostics of fine needle aspiration for the presurgical screening of thyroid nodules.Current genomics · 2014Article
- Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers.British journal of cancer · 2013Article
- Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Stable feature selection and classification algorithms for multiclass microarray data.Biology direct · 2012Article
- A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas.British journal of cancer · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancers have been the main medical consequence of the Chernobyl accident. On the basis of their pathological features and of the fact that a large proportion of them demonstrate RET-PTC translocations, these cancers are considered as similar to classical sporadic papillary carcinomas, although molecular alterations differ between both tumours. We analysed gene expression in post-Chernobyl cancers, sporadic papillary carcinomas and compared to autonomous adenomas used as controls. Unsupervised clustering of these data did not distinguish between the cancers, but separates both cancers from adenomas. No gene signature separating sporadic from post-Chernobyl PTC (chPTC) could be found using supervised and unsupervised classification methods although such a signature is demonstrated for cancers and adenomas. Furthermore, we demonstrate that pooled RNA from sporadic and chPTC are as strongly correlated as two independent sporadic PTC pools, one from Europe, one from the US involving patients not exposed to Chernobyl radiations. This result relies on cDNA and Affymetrix microarrays. Thus, platform-specific artifacts are controlled for. Our findings suggest the absence of a radiation fingerprint in the chPTC and support the concept that post-Chernobyl cancer data, for which the cancer-causing event and its date are known, are a unique source of information to study naturally occurring papillary carcinomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.