ArticleApplied and environmental microbiology2005
Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeae.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 133 citations in OpenAlex.
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- Recent advances in the discovery, biosynthesis, and therapeutic potential of isocoumarins derived from fungi: a comprehensive update.RSC advances · 2023Review
- Fusarium fruiting body microbiome member Pantoea agglomerans inhibits fungal pathogenesis by targeting lipid rafts.Nature microbiology · 2022Article
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- Genome editing using preassembled CRISPR-Cas9 ribonucleoprotein complexes in Fusarium graminearum.PloS one · 2022Article
- Tissue-specific transcriptome responses to Fusarium head blight and Fusarium root rot.Frontiers in plant science · 2022Article
- S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence inVirulence · 2021Article
- CRISPR/Cas9 mediated editing of the Quorn fungus Fusarium venenatum A3/5 by transient expression of Cas9 and sgRNAs targeting endogenous marker gene PKS12.Fungal biology and biotechnology · 2021Article
- The sustainable cycle of a new cacao-based bioplastic: from manufacturing to exploitable biodegradation products.RSC advances · 2021Article
- Laccase Properties, Physiological Functions, and Evolution.International journal of molecular sciences · 2020Review
- Advances in linking polyketides and non-ribosomal peptides to their biosynthetic gene clusters in Fusarium.Current genetics · 2019Review
- Putative metabolic pathway for the bioproduction of bikaverin and intermediates thereof in the wild Fusarium oxysporum LCP531 strain.AMB Express · 2019Article
- Evidence of a Demethylase-Independent Role for the H3K4-Specific Histone Demethylases inFrontiers in microbiology · 2019Article
- Thioredoxin Reductase Is Involved in Development and Pathogenicity inFrontiers in microbiology · 2019Article
- Comprehensive Description ofFoods (Basel, Switzerland) · 2018Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycelia of Gibberella zeae (anamorph, Fusarium graminearum), an important pathogen of cereal crops, are yellow to tan with white to carmine red margins. We isolated genes encoding the following two proteins that are required for aurofusarin biosynthesis from G. zeae: a type I polyketide synthase (PKS) and a putative laccase. Screening of insertional mutants of G. zeae, which were generated by using a restriction enzyme-mediated integration procedure, resulted in the isolation of mutant S4B3076, which is a pigment mutant. In a sexual cross of the mutant with a strain with normal pigmentation, the pigment mutation was linked to the inserted vector. The vector insertion site in S4B3076 was a HindIII site 38 bp upstream from an open reading frame (ORF) on contig 1.116 in the F. graminearum genome database. The ORF, designated Gip1 (for Gibberella zeae pigment mutation 1), encodes a putative laccase. A 30-kb region surrounding the insertion site and Gip1 contains 10 additional ORFs, including a putative ORF identified as PKS12 whose product exhibits about 40% amino acid identity to the products of type I fungal PKS genes, which are involved in pigment biosynthesis. Targeted gene deletion and complementation analyses confirmed that both Gip1 and PKS12 are required for aurofusarin production in G. zeae. This information is the first information concerning the biosynthesis of these pigments by G. zeae and could help in studies of their toxicity in domesticated animals.
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