ArticleRNA (New York, N.Y.)2005
Transcription and RNA-processing in fission yeast mitochondria.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts.Science (New York, N.Y.) · 2024Article
- Mitochondrial RNA maturation.RNA biology · 2024Review
- Mitochondrial genome of Cordyceps blackwelliae: organization, transcription, and evolutionary insights into Cordyceps.IMA fungus · 2023Article
- Mitochondrial genome annotation with MFannot: a critical analysis of gene identification and gene model prediction.Frontiers in plant science · 2023Article
- Mitochondrial Transcription of Entomopathogenic Fungi Reveals Evolutionary Aspects of Mitogenomes.Frontiers in microbiology · 2022Article
- TheRNA (New York, N.Y.) · 2018Article
- Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2.Protein & cell · 2017Article
- Functional and regulatory profiling of energy metabolism in fission yeast.Genome biology · 2016Article
- The transcriptome of Candida albicans mitochondria and the evolution of organellar transcription units in yeasts.BMC genomics · 2015Article
- Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe.The Journal of biological chemistry · 2013Article
- Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe.Nucleic acids research · 2011Article
- Transcription of the Dictyostelium discoideum mitochondrial genome occurs from a single initiation site.RNA (New York, N.Y.) · 2009Article
- Molecular evolution of the mtDNA encoded rps3 gene among filamentous ascomycetes fungi with an emphasis on the Ophiostomatoid fungi.Journal of molecular evolution · 2009Article
- The human mitochondrial ribosome recycling factor is essential for cell viability.Nucleic acids research · 2008Article
- The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome.BMC genomics · 2007Article
- A network of multiple regulatory layers shapes gene expression in fission yeast.Molecular cell · 2007Article
- RNA polyadenylation and degradation in different Archaea; roles of the exosome and RNase R.Nucleic acids research · 2006Article
- Bacterial/archaeal/organellar polyadenylation.Wiley interdisciplinary reviews. RNAReview
- Mitochondrial poly(A) polymerase and polyadenylation.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We systematically examined transcription and RNA-processing in mitochondria of the petite-negative fission yeast Schizosaccharomyces pombe. Two presumptive transcription initiation sites at opposite positions on the circular-mapping mtDNA were confirmed by in vitro capping of primary transcripts with guanylyl-transferase. The major promoter (Pma) is located adjacent to the 5'-end of the rnl gene, and a second, minor promoter (Pmi) upstream from cox3. The primary 5'-termini of the mature rnl and cox3 transcripts remain unmodified. A third predicted accessory transcription initiation site is within the group IIA1 intron of the cob gene (cobI1). The consensus promoter motif of S. pombe closely resembles the nonanucleotide promoter motifs of various yeast mtDNAs. We further characterized all mRNAs and the two ribosomal RNAs by Northern hybridization, and precisely mapped their 5'- and 3'-ends. The mRNAs have leader sequences with a length of 38 up to 220 nt and, in most instances, are created by removal of tRNAs from large precursor RNAs. Like cox2 and rnl, cox1 and cox3 are not separated by tRNA genes; instead, transcription initiation from the promoters upstream from rnl and cox3 compensates for the lack of tRNA-mediated 5'-processing. The 3'-termini of mRNAs and of SSU rRNA are processed at distinct, C-rich motifs that are located at a variable distance (1-15 nt) downstream from mRNA and SSU-rRNA coding regions. The accuracy of RNA-processing at these sites is sequence-dependent. Similar 3'-RNA-processing motifs are present in species of the genus Schizosaccharomyces, but not in budding yeasts that have functionally analogous A+T-rich dodecamer processing signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.