ArticleEnvironmental health perspectives2005
Pulmonary effects of indoor- and outdoor-generated particles in children with asthma.
Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- The Association Between Personal Air Pollution Exposures and Fractional Exhaled Nitric Oxide (FeNO): A Systematic Review.Current environmental health reports · 2024Pooled it
- Patterns and predictors of air purifier adherence in children with asthma living in low-income, urban households.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Trial
- Interaction of ambient air pollution with asthma medication on exhaled nitric oxide among asthmatics.Archives of environmental & occupational health · 2009Trial
- Comparison of personal portable and fixed-site PMScientific reports · 2026Article
- Observational
- Article
- Predictive Factors and Clinical Markers of Recurrent Wheezing and Asthma After RSV Infection.Viruses · 2025Review
- Investigating the Consequences of Measurement Error of Gradually More Sophisticated Long-Term Personal Exposure Models in Assessing Health Effects: The London Study (MELONS).Research report (Health Effects Institute) · 2025Article
- Air pollution and respiratory health in patients with COPD: should we focus on indoor or outdoor sources?Thorax · 2024Article
- Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort.The Science of the total environment · 2023Article
- High levels of indoor fine particulate matter during the cold season in Almaty prompt urgent public health action.PloS one · 2023Article
- Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2021Article
- The contribution of cooking appliances and residential traffic proximity to aerosol personal exposure.Journal of environmental health science & engineering · 2021Article
- Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction.Journal of the American Heart Association · 2021Article
- Bad Air Can Also Kill: Residential Indoor Air Quality and Pollutant Exposure Risk during the COVID-19 Crisis.International journal of environmental research and public health · 2020Article
- A framework for estimating the US mortality burden of fine particulate matter exposure attributable to indoor and outdoor microenvironments.Journal of exposure science & environmental epidemiology · 2020Article
- Fine-Scale Modeling of Individual Exposures to Ambient PMAtmosphere · 2020Article
- Characteristics of indoor and outdoor fine particles in heating period at urban, suburban, and rural sites in Harbin, China.Environmental science and pollution research international · 2020Article
- Short-term effect of PMEnvironmental science and pollution research international · 2019Article
- Particulate matters and gaseous pollutants in indoor environment and Association of ultra-fine particulate matters (PMEnvironmental science and pollution research international · 2019Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Most particulate matter (PM) health effects studies use outdoor (ambient) PM as a surrogate for personal exposure. However, people spend most of their time indoors exposed to a combination of indoor-generated particles and ambient particles that have infiltrated. Thus, it is important to investigate the differential health effects of indoor- and ambient-generated particles. We combined our recently adapted recursive model and a predictive model for estimating infiltration efficiency to separate personal exposure (E) to PM2.5 (PM with aerodynamic diameter < or = 2.5 microm) into its indoor-generated (Eig) and ambient-generated (Eag) components for 19 children with asthma. We then compared Eig and Eag to changes in exhaled nitric oxide (eNO), a marker of airway inflammation. Based on the recursive model with a sample size of eight children, Eag was marginally associated with increases in eNO [5.6 ppb per 10-microg/m3 increase in PM2.5; 95% confidence interval (CI), -0.6 to 11.9; p = 0.08]. Eig was not associated with eNO (-0.19 ppb change per 10 microg/m3). Our predictive model allowed us to estimate Eag and Eig for all 19 children. For those combined estimates, only Eag was significantly associated with an increase in eNO (Eag: 5.0 ppb per 10-microg/m3 increase in PM2.5; 95% CI, 0.3 to 9.7; p = 0.04; Eig: 3.3 ppb per 10-microg/m3 increase in PM2.5; 95% CI, -1.1 to 7.7; p = 0.15). Effects were seen only in children who were not using corticosteroid therapy. We conclude that the ambient-generated component of PM2.5 exposure is consistently associated with increases in eNO and the indoor-generated component is less strongly associated with eNO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.