ReviewCurrent atherosclerosis reports2005
Coronary heart disease and polymorphisms in genes affecting lipid metabolism and inflammation.
Review in Current atherosclerosis reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Distinctive serum lipidomic profile of IVIG-resistant Kawasaki disease children before and after treatment.PloS one · 2023Article
- Association of BAX hypermethylation with coronary heart disease is specific to individuals aged over 70.Medicine · 2019Article
- Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan.Journal of genetic syndromes & gene therapy · 2014Article
- Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer.Cancer causes & control : CCC · 2011Review
- Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach.Journal of molecular medicine (Berlin, Germany) · 2007Article
- APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study.Journal of molecular medicine (Berlin, Germany) · 2007Article
- Genetics of macrovascular complications in diabetes.Current diabetes reports · 2006Review
- The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.Journal of medical genetics · 2006Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several biologic systems contribute to the pathophysiology of atherosclerosis and its complications, and within each of these systems many genes have been explored to establish the possible implication of their variability in coronary heart disease (CHD) risk. This report is focused on recent results pertaining to lipid and inflammatory genes, their variability, and their relationship with intermediate phenotypes and CHD. For both systems, there is no evidence at the present time that testing genetic polymorphisms might be of any benefit to the patient, for the diagnosis or prognosis of CHD, or for tailoring drug prescription. Understanding the genetics of complex traits like CHD will require a system approach that allows a modeling of the interaction among genes as well as between genetic and nongenetic sources of variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.