ReviewDigestive diseases and sciences2005
How to make a Barrett esophagus: pathophysiology of columnar metaplasia of the esophagus.
Review in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Tetrahydroxylated bile acids prevents malignant progression of Barret esophagusWorld journal of gastroenterology · 2025Article
- Article
- Cryospray ablation using pressurized CO2 for ablation of Barrett's esophagus with early neoplasia: early termination of a prospective series.Endoscopy international open · 2015Article
- Barrett oesophagus: lessons on its origins from the lesion itself.Nature reviews. Gastroenterology & hepatology · 2015Review
- Toll-like receptor 4 activation in Barrett's esophagus results in a strong increase in COX-2 expression.Journal of gastroenterology · 2014Article
- Chronic pepsin exposure promotes anchorage-independent growth and migration of a hypopharyngeal squamous cell line.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Article
- Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus.World journal of gastroenterology · 2013Article
- Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract.BMC gastroenterology · 2012Article
- Intercellular space volume is mainly increased in the basal layer of esophageal squamous epithelium in patients with GERD.Digestive diseases and sciences · 2011Article
- Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus.PloS one · 2011Article
- Biology of Barrett's esophagus and esophageal adenocarcinoma.Gastrointestinal endoscopy clinics of North America · 2011Review
- Platelet 12-lipoxygenase and stem cells in Barrett's esophagus.Oncology letters · 2010Article
- The role of acid and bile reflux in oesophagitis and Barrett's metaplasia.Biochemical Society transactions · 2010Review
- Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.Progress in molecular biology and translational science · 2010Review
- Induction of intestinalization in human esophageal keratinocytes is a multistep process.Carcinogenesis · 2009Article
- Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers.BMC gastroenterology · 2008Article
- Characterization of esophageal submucosal glands in pig tissue and cultures.Digestive diseases and sciences · 2007Article
- Molecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics.Journal of molecular medicine (Berlin, Germany) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Barrett esophagus is defined as a specialized intestinal replacing the squamous epithelium of the esophageal mucosa in response to gastroesophageal reflux. Barrett metaplasia is a healing process that develops to protect the esophagus from further damage. Although mechanisms by which Barrett metaplasia evolves toward dysplasia and adenocarcinoma have been extensively studied, the process by which squamous epithelium is replaced by specialized intestinal metaplasia is poorly understood. Barrett esophagus develops when defense mechanisms in the esophageal mucosa (luminal secretion of mucus, bicarbonate, growth factors, etc.) are overwhelmed by an ongoing cycle of mucosal injury and repair. Hydrogen ion, pepsin, trypsin, and bile acids are considered harmful agents that synergistically invade the esophageal mucosa. Areas of destroyed squamous epithelium are then progressively reepithelized by a columnar epithelium that may originate from multipotent stem cells located within the basal layer of the normal esophageal mucosa or in the ducts of submucosal glands.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.