ArticleProceedings of the National Academy of Sciences of the United States of America2005
Olfactory expression of a single and highly variable V1r pheromone receptor-like gene in fish species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 123 citations in OpenAlex.
- Chemical cues and molecular mechanisms suspected in abiotic stress communication.The Journal of experimental biology · 2026Article
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Possible Involvement of Ghost Introgressions in the Striking Diversity of Vomeronasal Type 1 Receptor Genes in East African Cichlids.Ecology and evolution · 2025Article
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- Extraoral expression and characterization of bitter taste receptors inFASEB bioAdvances · 2022Article
- A comprehensive structural, lectin and immunohistochemical characterization of the zebrafish olfactory system.Scientific reports · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts.The Journal of biological chemistry · 2019Article
- The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease.International journal of molecular sciences · 2019Review
- Comparative Genomics Reveals Accelerated Evolution of Fright Reaction Genes in Ostariophysan Fishes.Frontiers in genetics · 2019Article
- Genome sequence of walking catfish (Clarias batrachus) provides insights into terrestrial adaptation.BMC genomics · 2018Article
- Article
- Early social learning triggers neurogenomic expression changes in a swordtail fish.Proceedings. Biological sciences · 2017Article
- Identification of olfactory receptor genes in the Japanese grenadier anchovyGenes & genomics · 2017Article
- Article
- Zebrafish olfactory receptor ORA1 recognizes a putative reproductive pheromone.Communicative & integrative biology · 2014Article
- Multiple episodic evolution events in V1R receptor genes of East-African cichlids.Genome biology and evolution · 2014Article
- The molecular evolutionary dynamics of the vomeronasal receptor (class 1) genes in primates: a gene family on the verge of a functional breakdown.Frontiers in neuroanatomy · 2014Review
- The sea lamprey has a primordial accessory olfactory system.BMC evolutionary biology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Sensory neurons expressing members of the seven-transmembrane V1r receptor superfamily allow mice to perceive pheromones. These receptors, which exhibit no sequence homology to any known protein except a weak similarity to taste receptors, have only been found in mammals. In the mouse, the V1r repertoire contains >150 members, which are expressed by neurons of the vomeronasal organ, a structure present exclusively in some tetrapod species. Here, we report the existence of a single V1r gene in multiple species of a non-terrestrial, vomeronasal organ-lacking taxon, the teleosts. In zebrafish, this V1r gene is expressed in chemosensory neurons of the olfactory rosette with a punctate distribution, strongly suggesting a role in chemodetection. This unique receptor gene exhibits a remarkably high degree of sequence variability between fish species. It likely corresponds to the original V1r present in the common ancestor of vertebrates, which led to the large and very diverse expansion of vertebrate pheromone receptor repertoires, and suggests the presence of V1rs in multiple nonmammalian phyla.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.