ArticleProceedings of the National Academy of Sciences of the United States of America2005
Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.Plant communications · 2025Review
- Pervasiveness of Microprotein Function AmongstCells · 2024Article
- Shining a light on the dark proteome: Non-canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology.Protein science : a publication of the Protein Society · 2023Review
- Murine Falcor/LL35 lncRNA Contributes to Glucose and Lipid Metabolism In Vitro and In Vivo.Biomedicines · 2022Article
- Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses.Frontiers in genetics · 2021Article
- The physiological function of long-noncoding RNAs.Non-coding RNA research · 2020Review
- Genome-Wide Analysis Reveals Changes in Long Noncoding RNAs in the Differentiation of Canine BMSCs into Insulin-Producing Cells.International journal of molecular sciences · 2020Article
- When Long Noncoding Becomes Protein Coding.Molecular and cellular biology · 2020Review
- Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems.PloS one · 2020Article
- MIEF1 Microprotein Regulates Mitochondrial Translation.Biochemistry · 2018Article
- Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species.BMC genomics · 2018Article
- Identification of target genes regulated by the Drosophila histone methyltransferase Eggless reveals a role of Decapentaplegic in apoptotic signaling.Scientific reports · 2018Article
- Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs.Cellular and molecular life sciences : CMLS · 2018Review
- Encoding activities of non-coding RNAs.Theranostics · 2018Review
- Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension.Frontiers in pharmacology · 2018Review
- Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- LncRNA mediated regulation of aging pathways inAging · 2016Article
- Investigating long noncoding RNAs using animal models.The Journal of clinical investigation · 2016Review
- Comparative Expression Dynamics of Intergenic Long Noncoding RNAs in the Genus Drosophila.Genome biology and evolution · 2016Article
- Genome-wide identification and developmental expression profiling of long noncoding RNAs during Drosophila metamorphosis.Scientific reports · 2016Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Analysis of EST and cDNA collections from a number of metazoan species has identified genes encoding long polyadenylated transcripts that do not contain ORFs of lengths typical for protein-encoding mRNAs. Noncoding functions of such polyadenylated transcripts have been elucidated in only a few examples. The corresponding genes neither contain hallmark sequence motifs nor appear to have been conserved across phyla. Thus, it is impossible to systematically identify new members of this class of gene by using sequence homology and traditional gene-finding algorithms that depend on protein-coding potential. Consequently, even their approximate number has not been established for any metazoan genome. We curated polyadenylated transcripts with limited protein-coding capacity from intergenic regions of the Drosophila melanogaster genome. We used RT-PCR assays, hybridization to RNA blots and whole-mount embryos, and computational analyses to characterize candidate transcripts. We verify the structures and expression of 17 distinct, likely non-protein-coding polyadenylated transcripts. We show that the expression of many of these transcripts is conserved in other Drosophila species, indicating that they have important biological functions.
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