ArticleProceedings of the National Academy of Sciences of the United States of America2005
Memory T cells have gene expression patterns intermediate between naive and effector.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2018Trial
- In-vitro model to mimic T cell subset change in human PDAC organoid co-culture.Journal of cancer research and clinical oncology · 2023Article
- Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers: Appraising Exercise-Induced Immuno-Modulation As An Integral Mechanism.Frontiers in oncology · 2022Review
- Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model.Cancers · 2021Article
- B Cells Control Mucosal-Associated Invariant T Cell Responses toFrontiers in immunology · 2021Article
- Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity.Journal for immunotherapy of cancer · 2019Article
- Regenerating Immunotolerance in Multiple Sclerosis with Autologous Hematopoietic Stem Cell Transplant.Frontiers in immunology · 2018Review
- Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities.The Journal of clinical investigation · 2016Article
- Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells.Scientific reports · 2016Article
- Asymmetric Cell Division in T Lymphocyte Fate Diversification.Trends in immunology · 2015Review
- Lineage relationship of effector and memory T cells.Current opinion in immunology · 2013Review
- FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level.Frontiers in immunology · 2013Article
- Paths to stemness: building the ultimate antitumour T cell.Nature reviews. Cancer · 2012Review
- The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation.Nature reviews. Immunology · 2012Review
- Article
- Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses.The Journal of biological chemistry · 2011Article
- A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy.Immunity · 2009Article
- Article
- Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological basis underlying differentiation of naive (NAI) T cells into effector (EFFE) and memory (MEM) cells is incompletely understood. Furthermore, whether NAI T cells serially differentiate into EFFE and then MEM cells (linear differentiation) or whether they concurrently differentiate into either EFFE or MEM cells (parallel differentiation) remains unresolved. We isolated NAI, EFFE, and MEM CD8(+) T cell subsets from human peripheral blood and analyzed their gene expression by using microarrays. We identified 156 genes that strongly differentiate NAI, EFFE, and MEM CD8(+) T cells; these genes provide previously unrecognized markers to help identify each cell type. Using several statistical approaches to analyze and group the data (standard heat-map and hierarchical clustering, a unique circular representation, multivariate analyses based on principal components, and a clustering method based on phylogenetic parsimony analysis), we assessed the lineage relationships between these subsets and showed that MEM cells have gene expression patterns intermediate between NAI and EFFE T cells. Our analysis suggests a common differentiation pathway to an intermediate state followed by a split into EFFE or MEM cells, hence supporting the parallel differentiation model. As such, conditions under which NAI T cells are activated may determine the magnitude of both EFFE and MEM cells, which arise subsequently. A better understanding of these conditions may be very useful in the design of future vaccine strategies to maximize MEM cell generation.
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