ArticleThe Journal of cell biology2005
Class II fusion protein of alphaviruses drives membrane fusion through the same pathway as class I proteins.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- How SNARE proteins generate force to fuse membranes.Biophysical journal · 2025Article
- Review
- Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling.The Journal of membrane biology · 2022Article
- The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion.PLoS pathogens · 2021Article
- The Role of Zinc in Antiviral Immunity.Advances in nutrition (Bethesda, Md.) · 2019Review
- Monomeric Intermediates Formed by Vesiculovirus Glycoprotein during Its Low-pH-induced Structural Transition.Journal of molecular biology · 2018Review
- Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.Biochimica et biophysica acta. Biomembranes · 2018Article
- Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294.Scientific reports · 2015Article
- Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor.PLoS pathogens · 2015Article
- Lysophosphatidylcholine reversibly arrests pore expansion during syncytium formation mediated by diverse viral fusogens.Journal of virology · 2014Article
- Intermediate conformations during viral fusion glycoprotein structural transition.Current opinion in virology · 2013Review
- Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion.Journal of virology · 2012Article
- Molecular and cellular aspects of rhabdovirus entry.Viruses · 2012Article
- The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components.PLoS pathogens · 2011Article
- Fusing a lasting relationship between ER tubules.Trends in cell biology · 2011Review
- Structure and working of viral fusion machinery.Current topics in membranes · 2011Review
- Dengue virus ensures its fusion in late endosomes using compartment-specific lipids.PLoS pathogens · 2010Article
- Distinct structural rearrangements of the VSV glycoprotein drive membrane fusion.The Journal of cell biology · 2010Article
- Imaging multiple intermediates of single-virus membrane fusion mediated by distinct fusion proteins.Microscopy research and technique · 2010Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Viral fusion proteins of classes I and II differ radically in their initial structures but refold toward similar conformations upon activation. Do fusion pathways mediated by alphavirus E1 and influenza virus hemagglutinin (HA) that exemplify classes II and I differ to reflect the difference in their initial conformations, or concur to reflect the similarity in the final conformations? Here, we dissected the pathway of low pH-triggered E1-mediated cell-cell fusion by reducing the numbers of activated E1 proteins and by blocking different fusion stages with specific inhibitors. The discovered progression from transient hemifusion to small, and then expanding, fusion pores upon an increase in the number of activated fusion proteins parallels that established for HA-mediated fusion. We conclude that proteins as different as E1 and HA drive fusion through strikingly similar membrane intermediates, with the most energy-intensive stages following rather than preceding hemifusion. We propose that fusion reactions catalyzed by all proteins of both classes follow a similar pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.