ArticleNucleic acids research2005
Regulation of Id2 expression by CCAAT/enhancer binding protein beta.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- ID1 and CEBPA coordinate epidermal progenitor cell differentiation.Development (Cambridge, England) · 2022Article
- Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior.Cell and tissue research · 2022Review
- CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3.Scientific reports · 2018Article
- Inhibitor of binding/differentiation 2 (Id2) is regulated by CCAAT/enhancer-binding protein-α (C/EBPα) and promotes the proliferation of hepatocellular carcinoma.American journal of cancer research · 2018Article
- Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice.Journal of diabetes research · 2016Article
- Id transcriptional regulators in adipogenesis and adipose tissue metabolism.Frontiers in bioscience (Landmark edition) · 2014Review
- Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare.Reproductive biology and endocrinology : RB&E · 2014Article
- Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development.Blood · 2012Article
- JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-β.The Journal of cell biology · 2012Article
- CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.Neurobiology of aging · 2012Article
- Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.Nature medicine · 2012Article
- Peroxisome proliferator-activated receptorα agonists differentially regulate inhibitor of DNA binding expression in rodents and human cells.PPAR research · 2012Article
- Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development.Endocrinology · 2009Article
- Alveolar and lactogenic differentiation.Journal of mammary gland biology and neoplasia · 2006Review
- Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice deficient for Id2, a negative regulator of basic helix-loop-helix (bHLH) transcription factors, exhibit a defect in lactation due to impaired lobuloalveolar development during pregnancy, similar to the mice lacking the CCAAT enhancer binding protein (C/EBP) beta. Here, we show that Id2 is a direct target of C/EBPbeta. Translocation of C/EBPbeta into the nucleus, which was achieved by using a system utilizing the fusion protein between C/EBPbeta and the ligand-binding domain of the human estrogen receptor (C/EBPbeta-ERT), demonstrated the rapid induction of endogenous Id2 expression. In reporter assays, transactivation of the Id2 promoter by C/EBPbeta was observed and, among three potential C/EBPbeta binding sites found in the 2.3 kb Id2 promoter region, the most proximal element was responsible for the transactivation. Electrophoretic mobility shift assay (EMSA) identified this element as a core sequence to which C/EBPbeta binds. Chromatin immunoprecipitation (ChIP) furthermore confirmed the presence of C/EBPbeta in the Id2 promoter region. Northern blotting showed that Id2 expression in C/EBPbeta-deficient mammary glands was reduced at 10 days post coitus (d.p.c.), compared with that in wild-type mammary glands. Thus, our data demonstrate that Id2 is a direct target of C/EBPbeta and provide insight into molecular mechanisms underlying mammary gland development during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.