ReviewHIV medicine2005
Impact of highly active antiretroviral therapy on organ-specific manifestations of HIV-1 infection.
Review in HIV medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001137 (Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) Protocol
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Kidney dysfunction and associated factors among adults living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Research Trends in HIV-Associated Nephropathy (HIVAN) from 2015 to 2025: A Bibliometric Analysis Using CiteSpace.HIV/AIDS (Auckland, N.Z.) · 2026Review
- Renal Function Impairment and Associated Factors Among Adult HIV-Positive Patients Attending Antiretroviral Therapy Clinic in Mettu Karl Referral Hospital: Cross-Sectional Study.HIV/AIDS (Auckland, N.Z.) · 2021Article
- [Nontuberculous mycobacterial infections].Zeitschrift fur Rheumatologie · 2017Review
- Cervical cancer incidence after up to 20 years of observation among women with HIV.International journal of cancer · 2017Observational
- The Role of Nuclear Medicine in the Staging and Management of Human Immune Deficiency Virus Infection and Associated Diseases.Nuclear medicine and molecular imaging · 2017Review
- Article
- Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage.Journal of proteome research · 2010Article
- Article
- Adolescent HIV/AIDS: Issues and challenges.Indian journal of sexually transmitted diseases and AIDS · 2010Article
- Depletion of CD4+ T cells in semen during HIV infection and their restoration following antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989-2003.BMC cancer · 2008Article
- Neuropathologic contributions to understanding AIDS and the central nervous system.Brain pathology (Zurich, Switzerland) · 2007Review
- Maturing neurons are selectively sensitive to human immunodeficiency virus type 1 exposure in differentiating human neuroepithelial progenitor cell cultures.Journal of neurovirology · 2006Article
- Postmortem findings and opportunistic infections in HIV-positive patients from a public hospital in Peru.Pathology, research and practice · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last 10 years, interesting results have been reported concerning the impact of highly active antiretroviral therapy (HAART) on the changing pattern of organ-specific manifestations of HIV-1 infection. There has been a clear step-wise reduction in the incidence of several opportunistic infections (OIs), particularly Pneumocystis carinii pneumonia, whereas a nonsignificant reduction in incidence has been observed for other organ-specific diseases, including invasive cervical cancer and Hodgkin disease. In addition, several organ-specific manifestations, including HIV-associated nephropathy, wasting syndrome and cardiomyopathy, are a direct consequence of damage by HIV-1, and so HAART may have a therapeutic effect in improving or preventing these manifestations. Finally, the introduction of HAART has seen the emergence of several complications, termed immune reconstitution inflammatory syndrome, which includes OIs such as cytomegalovirus vitritis, Mycobacterium avium complex lymphadenitis, paradoxical responses to treatment for tuberculosis, and exacerbation of cryptococcosis. Because not all HIV-1 organ-specific manifestations are decreasing in the HAART era, this review will analyse the influence of HAART on several organ-specific manifestations, and in particular OIs related to several organs, cerebral disorders and HIV-1-related neoplasia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.